机构地区:[1]State Key Laboratory on Integrated Optoelectronics,Institute of Semiconductors,Chinese Academy of Sciences [2]State Key Laboratory on Integrated Optoelectronics,Institute of Semiconductors,Chinese Academy of Sciences, Beijing 100083, China [3]Department of Tissue Engineering, Institute of Basic Medical Sciences and Tissue Engineering Research Center,Academy of Military Medical Sciences
出 处:《Science China(Information Sciences)》2014年第4期204-213,共10页中国科学(信息科学)(英文版)
基 金:supported by National Natural Science Foundation of China(Grant Nos.61178082,31070965,61036002,61076023,61178051,61078074);National Basic Research Program of China(973 Program)(Grant Nos.2011CB933203,2011CB933102);National High-tech R&D Program of China(863 Program)(Grant No.2012AA030608)
摘 要:Platinum black coating can effectively improve the performance of MEAs (microelectrodes array) in neural signal transduction, though its lack of adhesion strength and durability tampers its usage in long term experiments. Here a new method of composite electrodeposition provides highly adhesive platinum black coating that enables MEAs for a month's long task and repeatable utilization. The new method was compared with present techniques on multiple aspects, e.g. actual surface area, surface morphology, interfacial impedance, durability and real application tests. Results show that the new composite coating provides greatly improved durability without compromising its performances. Neural cells were cultured on these MEAs for 40 days in vitro and spontaneous action potentials with high signal/noise ratio were recorded. Theoretical model and simulation provided preliminary understanding on the mechanism of this strengthened platinum black coating.Platinum black coating can effectively improve the performance of MEAs (microelectrodes array) in neural signal transduction, though its lack of adhesion strength and durability tampers its usage in long term experiments. Here a new method of composite electrodeposition provides highly adhesive platinum black coating that enables MEAs for a month's long task and repeatable utilization. The new method was compared with present techniques on multiple aspects, e.g. actual surface area, surface morphology, interfacial impedance, durability and real application tests. Results show that the new composite coating provides greatly improved durability without compromising its performances. Neural cells were cultured on these MEAs for 40 days in vitro and spontaneous action potentials with high signal/noise ratio were recorded. Theoretical model and simulation provided preliminary understanding on the mechanism of this strengthened platinum black coating.
关 键 词:microelectrode array platinum black ELECTROPLATING ELECTROPHYSIOLOGY neural culture
分 类 号:TQ153.1[化学工程—电化学工业]
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