清开灵注射液降压物质检查法建立的可行性研究  

The feasibility study to establish the depressor substances test method for Qingkailing Injections

作　　者：樊华[1] 康强[1] 焉媛媛[1] 林鹏[1] 王秀英[1] 

机构地区：[1]辽宁省食品药品检验所,沈阳110023

出　　处：《西北药学杂志》2014年第2期170-172,共3页Northwest Pharmaceutical Journal

摘　　要：目的建立清开灵注射液降压物质检查法。方法通过对9个生产企业22批清开灵注射液与组织胺对照品引起麻醉猫血压下降程度比较的研究,确定其降压物质检查法的限值。结果 9个生产企业22批清开灵注射液合格率达90.9%,不合格率9.1%。结论清开灵注射液降压物质检查限值确定为0.2mL·kg-1较为合理,建议清开灵注射液检验标准中增加降压物质检查。Objective To establish the depressor substances test of Qingkailing Injections .Methods The limit values of depressor substances Qingkailing Injections were determined by investigating the regulating action of Qingkailing Injections （22 batches of nine different manufacturer specifications ） and histamine for the blood pressure in the anesthetic cats .Results In the depressor substances test selecting 22 Qingkailing Injections of nine different manufacturer specifications ,the percent of pass was up to 90 . 9% ,defective fraction was 9 .1% .Conclusion The most suitable limit of test for depressor substances for Qingkailing Injections was 0 .2 mL ·kg ^-1 .The depressor substance test should be added in the quality standard of Qingkailing Injection .

关 键 词：清开灵注射液 降压物质 检查法 

分 类 号：R965[医药卫生—药理学]