盐酸替扎尼定口腔黏附片的研制及质量评价  

Preparation and quality evaluation of Mucoadhesive Buccal Tablets of Tiazanidine Hydrochloride

作　　者：杨晓艳[1] 张友智[1] 耿立坚[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《西北药学杂志》2014年第2期181-185,共5页Northwest Pharmaceutical Journal

摘　　要：目的制备盐酸替扎尼定口腔黏附片并评价其质量。方法采用不同配比的羟丙甲基纤维素(HPMC)、羧甲基纤维素钠(SCMC)、β-环糊精和羟丙基-β-环糊精等辅料,用直接压片法压片制备盐酸替扎尼定口腔黏附片,并对黏附片的理化性质、药物含量、药物体外释放度和黏附力进行评价。结果得到各项指标均较适宜的处方:盐酸替扎尼定4.56mg,羟丙甲纤维素20mg,羧甲基纤维素钠75mg,羟丙基-β-环糊精27.36mg,甘露醇4mg,阿斯巴甜1mg,微粉硅胶1mg。结论成功制备了盐酸替扎尼定口腔黏附片,可用于进一步的体内、体外研究。Objective To prepare and evaluate a buccal adhesive tablet containing tiazanidine hydrochloride .Methods The tablets were prepared by using hydroxypropyl methyl cellulose （HPMC ） ,sodium carboxymethylcellulose （SCMC ） ,β-cyclodextrin , hydroxypropyl-β-cyclodextrin ,etc as the auxiliary materials .Direct compression process was used to prepare the buccal adhesive tablets ,and different parameters such as physicochemical property ,drug content ,in vitro drug release ,and mucoadhesive strength were evaluated .Results The prescription was as follows ：tiazanidine hydrochloride 4 .56 mg ,hydroxypropyl methyl cellulose 20 mg ,sodium carboxymethylcellulose 75 mg ,hydroxypropyl-β-cyclodextrin 27 .36 mg ,mannitol 4 mg ,aspartame 1 mg and aerosil 1 mg .Conclusion The buccal adhesive tablets of tiazanidine hydrochloride were prepared successfully ,and which can be used for the further study both in vivo and in vitro .

关 键 词：替扎尼定 口腔黏附片 黏膜黏着剂 

分 类 号：R944[医药卫生—药剂学]