lncRNA作为抗肿瘤药物新靶点的机制及其研究进展  

The mechanism and research progress of lncRNA as potential antitumor drug targets

作　　者：刘雯清[1] 曹阳[1] 程滨[2] 唐淑兰 姜远英[1,4] 曹永兵[1,4] 

机构地区：[1]福建中医药大学药学院,福州350108 [2]第二军医大学科研部,上海200433 [3]甘肃省临夏州人民医院住院部药房,临夏州731100 [4]第二军医大学药学院新药研究中心,上海200433

出　　处：《西北药学杂志》2014年第2期215-219,共5页Northwest Pharmaceutical Journal

基　　金：上海市自然科学基金资助项目(编号:12ZR1437700)

摘　　要：目的综述lncRNA作为抗肿瘤药物新靶点的机制及其研究进展,揭示其研究趋势及方向。方法查阅近年来国内外相关文献,进行分析总结。结果与结论 lncRNA在肿瘤发生和发展中具有多重调节作用,以lncRNA为靶点开发抗肿瘤新药必将成为未来抗肿瘤药物研发的新趋势。Objective To review the mechanism and research progress of lncRNA as potential antitumor drug targets and reveal the research direction of lncRNA-targeted drugs .Methods Recent literatures were analyzed and summarized .Result and Conclu-sion LncRNA plays a multifunctional role in various cancers′onset and progression .LncRNA is a promising new trend for develo-ping lncRNA-targeted antitumor drugs .

关 键 词：抗肿瘤 药物靶点 

分 类 号：R979.1[医药卫生—药品]