癫痫证候和方药分布规律文献分析  

Literature Analysis of Pattern and Formula Distribution of Epilepsy

作　　者：司富春[1] 宋雪杰[1] 李洁[1] 杜超飞 

机构地区：[1]河南中医学院中医药分子生物学实验室

出　　处：《中医杂志》2014年第6期508-512,共5页Journal of Traditional Chinese Medicine

基　　金：河南省国际科技合作项目(104300510019);河南省创新型科技团队资助项目(2010-29);河南省博士后科研创新团队项目;郑州市技术研究与开发经费支持项目(10CXTD145);河南中医学院科技创新团队支持计划资助项目(2010XCXT05)

摘　　要：目的探讨癫痫中医证候分布规律和方药使用特点。方法检索1977年1月至2013年7月中国期刊全文数据库(CNKI)收录的中医及中西医结合诊治癫痫的临床研究和个人经验类文献,规范纳入文献中的证型及所用方剂和药物,并分别对其进行频数和聚类分析。结果纳入文献127篇。癫痫中医证型共计37个,其中风痰闭阻、肝风内动、痰瘀阻络、痰火扰神、痰蒙心神、肝肾阴虚证为主要证型;37个证型涉及风淫、火热、痰凝、血瘀、气滞、水湿、惊证、阴虚、气虚、血虚、阳虚等11个病机要素和肝、肾、心、脾、胃5个脏腑病位。癫痫出现频次较多的108个症状可聚成五大类,分别是气虚血瘀、痰瘀阻络、热极生风型;心脾两虚型;痰气闭阻、蒙蔽心神型;气阴两虚、津亏热结型;痰蒙心神型。共用方剂308首,成方69首,以祛痰剂、补益剂、和解剂、理血剂、清热剂、治风剂为主。共涉及中药251味20大类,以补虚、平肝熄风、化痰止咳平喘、活血化瘀、安神、理气、清热药为主。癫痫治疗使用频次较多的48味药可聚为六大类,分别为健脾益气、行气化痰、安神;清热泻火、理气化痰、养阴生津;活血化瘀、疏肝行气、定惊安神;清热化痰、重镇安神、行气活血;平肝潜阳、熄风止痉;行气化痰、开窍醒神。结论癫痫中医证候以风痰闭阻、肝风内动、痰瘀阻络、痰火扰神、痰蒙心神、肝肾阴虚证为主;组方用药以清热化痰、祛风止痉、理气活血、安神为重,并注重补虚剂的使用。Objective To study the TCM pattern distribution and formula cttaracterlsucs oi epitepsy. The articles on clinical research and personal experience in treating epilepsy with traditional Chinese medicine and integrative medicine from January 1977 to July 2013 were searched in China National Knowledge Infrastructure （CNKI）. The frequency analysis and cluster analysis was used to analyze the patterns, formulas and medicines. Results Totally 127 articles were included. There were 37 patterns, and the common patterns were wind-phlegm obstruction, liver wind stirring internally, phlegm-stasis obstructing the network vessels, phlegm-fire harassing the spirit, phlegm clouding the heart spirit, and fiver-kidney yin deficiency. The 37 patterns were related to 11 pathogenesis factors such as wind excess, fire-heat, phlegm congealing, blood stasis, qi stagnation, water-damp, fright pattern, yin deficiency, qi deficiency, blood deficiency, and yang deficiency, and 5 organs such as liver, kidney, heart, spleen, and stomach. The frequent 108 symptoms of epilepsy can be clustered into five patterns such as pattern of qi deficiency blood stasis, phlegm-stasis obstructing the network vessels and extreme heat engendering wind, pattern of heart-spleen deficiency, pattern of phlegm-qi obstructing and clouding the heart spirit, pattern of qi-yin deficiency and liquid depletion with heat bind, and pattern of phlegm clouding the heart spirit. There were 308 formulas and 69 set formulas could be grouped into 14 categories. The commonly used formulas were phlegm-expelling formula, supple- menting formula, harmonizing resolution formula, blood-rectifying formula, heat-clearing formula, and wind- controlling formula. There were 251 medicines included, which could be grouped into 20 categories such as supplementing medicinal, liver-calming wind-extinguishing medicinal, phlegm-transforming cough-suppressing panting- calming medicinal, blood-quickening stasis-transforming medicinal, spirit-quieting medicinal, qi-rectifying medicinal

关 键 词：癫痫 证候分布 方药特点 聚类分析 

分 类 号：R277.7[医药卫生—中医学]