芪参益气滴丸预处理对瓣膜置换患者右心功能的影响  

Effect of pretreatment with Qishen Yiqi dropping pills on right cardiac function of patients undergoing valve replacement

作　　者：崔振田[1,2] 魏万林[1] 刘梅[1] 王文静[3] 

机构地区：[1]解放军北京军区总医院心血管病研究中心,北京100700 [2]解放军第三军医大学,重庆400038 [3]河北医科大学第一附属医院,河北石家庄050031

出　　处：《中国中药杂志》2014年第5期916-919,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81273971)

摘　　要：该研究中风湿性心脏病瓣膜置换术患者120例,随机分成对照组60例和芪参组60例。术前对照组常规强心、利尿治疗基础上,应用芪参益气滴丸安慰剂,每次0.5 g,每日3次,餐后0.5 h服用,连续7 d;芪参组在常规治疗的基础上,应用芪参益气滴丸,每次0.5 g,每日3次,餐后0.5 h服用,连续7 d。术后1,6周测量右心室舒张期末容积(RVEDV)、右心室收缩期末容积(RVESV)、每搏输出量(SV)和右室射血分数(RVEF)。发现2组患者右心室舒张期末容积(RVEDV)、右心室收缩期末容积(RVESV)、每搏输出量(SV)显著低于手术前,而射血分数(RVEF)较术前明显升高,但芪参组术后右心功能降低程度显著低于对照组,差异具有统计学意义(P<0.05)。说明芪参益气滴丸预处理对风心瓣膜置换术后右心功能的改善有显著疗效。In this study, 120 patients with rheumatic heart disease undergoing valve replacement were randomly divided into the control group and the Qishen group, with 60 cases in each group. Before the operation, the control group was given routine heart and diuretic treatments and placebo of Qishen Yiqi dropping pills for seven days （0. 5 g each time, three times a day） ; While the Qishen group was given Qishen Yiqi dropping pills for seven days （0. 5 g each time after meal, three times a day） on the basis of the routine treatments. The right ventricular end-diastolic volume （ RVEDV）, end-systolic volume （ RVESV）, stroke volume （SV） and right ventricular ejection fraction （RVEF） were detected after the operation. The results showed that patients in the two groups showed significantly lower right ventricular end diastolic volume （RVEI）V）, right ventricular end systolic volume （RVESV） and stroke volume （SV） decreased than that before the operation, but with significantly higher Ejection fraction （RVEF） significantly than that before the operation. However, the Qishen group showed a significantly lower right heart function reduction than the control group, with the statis- tical significance in the differences （P 〈 0. 05）. This indicated that the pretreatment with Qishenyiqi Drop Pills showed a remarkable efficacy in the improvement of right ventricular function after valve replacement.

关 键 词：芪参益气滴丸 风湿性心脏病 瓣膜置换 右心功能 

分 类 号：R654.2[医药卫生—外科学]