肺表面活性蛋白研究进展  

Research Progress of Pulmonary Surfactant Proteins

作　　者：孟庆雪[1] 刘玉芬[1] 刘静[1] 吴迪[1] 

机构地区：[1]哈尔滨师范大学生命科学与技术学院,黑龙江哈尔滨150025

出　　处：《中国畜牧兽医》2014年第3期178-181,共4页China Animal Husbandry & Veterinary Medicine

基　　金：肺表面活性蛋白与鸡IBV感染的相关性(11H011)

摘　　要：肺表面活性蛋白是磷脂发挥功能的重要载体,主要分布于支气管表面和肺泡气—液界面,具有降低表面张力的特性,可防止肺泡塌陷,有利于气体交换,维持肺残气量和保持肺部的顺应性。目前已发现4种蛋白,分别是SP-A、SP-B、SP-C和SP-D。这4种蛋白在肺部疾病防御及肺功能的维持中起重要作用。因此,作者从SP的结构、功能及其与疾病的相关性方面进行综述,为今后的研究提供基础依据。Pulmonary surfactant protein （SP） is a carrier which plays an important role in phospholipids, mainly in the bronchial surface and alveolar gas-liquid interface, with lower surface tension properties, prevents alveolar collapse, is benefi- cial to gas exchange and to maintain the lungs pulmonary residual volume and to keep pulmonary compliance. Four kinds of pro- teins have been found, namely SP-A, SP-B, SP C and SP-D. These four proteins in lung disease defensive and in maintaining lung function play important roles. Therefore, this article reviews SP from its structure, function and the correlation with the disease, to provide a basis for future research.

关 键 词：肺表面活性蛋白 结构 功能 疾病 相关性 

分 类 号：Q51[生物学—生物化学]