高血铅对幼儿神经行为的影响  

Impact of Elevated Blood Lead Level on Neurobehavior in Children

作　　者：张小康[1] 邹时朴[1] 张琳[2] 李国林[2] 

机构地区：[1]江西省儿童医院儿童保健科 [2]南昌大学第二附属医院儿科,南昌330006

出　　处：《南昌大学学报（医学版）》2013年第11期67-68,71,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨高血铅对幼儿神经行为的影响。方法选择血铅≥100μg·L-1的33例儿童作为高血铅组,血铅<100μg·L-1的33例儿童作为对照组。采用幼儿行为量表对2组儿童的社交退缩、忧郁、睡眠问题、躯体诉述、攻击、破坏6个行为因子进行评分。结果高血铅组发生忧郁、攻击的比例分别为45.5%、81.8%,显著高于对照组的12.1%、48.5%(P<0.01)。高血铅组行为因子总得分为(60.36±27.66)分,对照组为(41.73±23.84)分,高血铅组显著高于对照组(Z=-2.937,P=0.003);2组社交退缩、忧郁、躯体诉述、攻击、破坏5个行为因子得分比较差异均有统计学意义(P<0.05)。结论高血铅儿童发生神经行为异常较正常儿童增多,对高血铅儿童采取积极有效的预防、干预措施,是儿童健康成长的重要保证。Objective To investigate the effect of elevated blood lead level on neurobehavior in children. Methods Thirty-three children with elevated blood lead level （blood lead elevation group ≥100 ug . L-1） and 33 normal children （control group,（100ug . L-1） were recruited in this study. Achenbach Child Behavior Checklist was used to evaluate social withdrawal, depression,sleep problems, somatic complaints, attack and destruction in both groups. Results Compared with control group, the incidences of depression and attack significantly increased in blood lead elevationgroup（45.5% vs 12.1% and 81.8% vs 48.5%,respectively,P〈0.01）- Furthermore, total behavior checklist score in blood lead elevation group（60.36 ± 27.66） was significantly higher than that in control group（41. 73 ± 23. 84） （Z=- 2. 937, P = 0. 003）. In addition, the differences in behavior checklist scores for social withdrawal, depression, somatic complaints, attack and destruction were significant between the two groups（P〈0.05）. Conclusion Compared with normal children, abnormal behaviors increase in children with elevated blood lead level. Therefore, positive and effective prevention and intervention should be performed to ensure healthy growth of children with elevated Blood lead level.

关 键 词：高血铅 幼儿 神经行为 

分 类 号：R179[医药卫生—妇幼卫生保健]