充血性心力衰竭患者甲状腺激素水平及临床意义  

Levels of thyroid hormone and its clinical significance in patients with congestive heart failure

作　　者：荆文庆[1] 姜清茹[1] 薛朝阳[1] 

机构地区：[1]宁夏银川第一人民医院心内科,宁夏银川750001

出　　处：《宁夏医学杂志》2001年第2期69-70,共2页Ningxia Medical Journal

摘　　要：目的　探讨充血性心力衰竭 (CHF)患者血清甲状腺激素 (TH)的变化及临床意义。方法　用放射免疫法测定 30例CHF患者及 30例健康对照者血清三碘甲状腺原氨酸 (T3)、四碘甲状腺素 (T4 )、促甲状腺激素(TSH)水平。结果　CHF患者血清T3、T4 、TSH水平分别为 0 .8± 0 .2 8ng/ml、82 .2 1± 14.82ng/ml、5 .45± 2 .0 6mIU/L ,其中T3、T4 水平明显低于对照组 (P <0 .0 1,P <0 .0 5 ) ;治疗后分别为 1.38± 0 .30ng/ml、95 .34± 15 .82ng/ml、5 .35± 3 .10mIU/L ,T3、T4 增高与治疗前比较有显著性差异 (P <0 .0 1,P <0 .0 5 )。结论　CHF患者体内T3、T4 水平下降 ,且与CHF病情呈负相关 ,观察TH水平变化对判断CHF患者的病情、疗效及预后有一定临床意义。Objectives In order to determine the levels of thyroid hormone(TH)and its clinical significance in patients with congestive heart failure(CHF).Methods The triiodothyronine(T 3),thyroxine(T 4),thyroid stimulating hormone(TSH)in serum of 30 patients with CHF and 30 normal Contrasts were detected by radioimmunoassay.Results The concentrations of T 3、T 4、TSH were 0.8±0.28ng/ml,82.21±14.82ng/ml,5.45±2.06mIU/L respectively in CHF patients and the levels of T 3、T 4 of patient were lower than that of normal contrasts (P<0.01,P<0.05respectively);The concentrations of T 3,T 4,TSH were 1.38±0.30ng/ml,95.34±15.82ng/ml,5.35±3.10mIU/L,respectively in CHF patients after treatment,the level of T 3、T 4 were higher than patient of CHF were not treated,there was significant difference (P<0.01,P<0.05,respectively).Conclusions The levels of T 3,T 4 in CHF patients is decreased,the more severe heart failure,the more obvious decreased of the hormones were observed.These indicate that the alterations of serum thyroid hormone level may be valuable to dentify the deterioration of heart function,the effect of treatment and prognosis in patients with congestive heart failure.

关 键 词：充血性心力衰竭 甲状腺激素 CHF TH 

分 类 号：R541.61[医药卫生—心血管疾病]