危重新生儿全身炎症反应综合征和多器官功能不全综合征的临床分析  

Clinical analysis of systemic inflammatory response syndrome and multiple organ dysfunction syndrome in neonate with critical illness

作　　者：陈弘 吴福根 吴旭丽 林彩华 

机构地区：[1]浙江省温岭市第一人民医院儿科,317500

出　　处：《中国全科医学》2001年第2期110-111,共2页Chinese General Practice

摘　　要：目的　探讨危重新生儿全身炎症反应综合征 (SIRS)及多器官功能不全综合征 (MODS)的预后及影响因素。方法　回顾性地总结分析我院新生儿重症监护病房 (NICU) ,于 1997年 1月～ 1999年 12月收治的危重新生儿 ,根据Hayden修订的SIRS诊断标准和全国小儿急诊学组拟定的MOF诊断标准进行临床分析。 结果2 5 2例危重儿 ,符合SIRS诊断标准的 16 1例 ,占 6 3 9%。最终发展为MODS的 84例 ,占 5 2 2 % ,死亡 32例 ,病死率为 38 1%。产伤、窒息、患儿成熟度及胎粪羊水污染易发展为MODS ,死亡率明显高于非MODS组。结论SIRS和MODS在NICU中发生率和病死率均高 ,而围产因素严重影响其预后 。Objective To evaluate the prognosis and the relation between systemic inflammatory response syndrome(SIRS)and multiple organ dysfunction syndrome (MODS)in neonatal intensive care units(NICU).Methods According to the criteria of SIRS by Hayden and MOF by Chinese Pediatric Emergency Association,252 critical illness were studied from January 1997 to December 1999.Results Among 252 critical newborn,161 cases (64%) were diagnosed as SIRS,84 cases(84/161) developed MODS,32 died,the mortality rate of MODS was 38 1%.The risk factors of MODS included birth trauma,degree of asphyxia,gestational age and meconium-stained amniotic fluid,which were associated with an increased risk of to MODS.The mortality in MODS was higher than that in non-MODS group.Conclusion SIRS/MODS is common in NICU and its mortality high.The prognosis is related with perinatal factors.We believe that early intervention should be taken in such cases.

关 键 词：全身炎症反应综合征 多器官功能不全综合征 新生儿 SIRS MODS 

分 类 号：R720.597[医药卫生—急诊医学] R725.9[医药卫生—儿科]