Relative Specificity:All Substrates Are Not Created Equal  

作　　者：Yan Zeng 

机构地区：[1]Department of Medicine,Masonic Cancer Center,University of Minnesota,Minneapolis,MN 55455,USA

出　　处：《Genomics, Proteomics & Bioinformatics》2014年第1期1-7,共7页基因组蛋白质组与生物信息学报（英文版）

基　　金：partly supported by the National Institutes of Health(Grant Nos.5P50-DA011806-12 and R01DA031202)

摘　　要：A biological molecule,e.g.,an enzyme,tends to interact with its many cognate substrates,targets,or partners differentially.Such a property is termed relative specificity and has been proposed to regulate important physiological functions,even though it has not been examined explicitly in most complex biochemical systems.This essay reviews several recent large-scale studies that investigate protein folding,signal transduction,RNA binding,translation and transcription in the context of relative specificity.These results and others support a pervasive role of relative specificity in diverse biological processes.It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems,which has significant implications in disease processes as well.A biological molecule,e.g.,an enzyme,tends to interact with its many cognate substrates,targets,or partners differentially.Such a property is termed relative specificity and has been proposed to regulate important physiological functions,even though it has not been examined explicitly in most complex biochemical systems.This essay reviews several recent large-scale studies that investigate protein folding,signal transduction,RNA binding,translation and transcription in the context of relative specificity.These results and others support a pervasive role of relative specificity in diverse biological processes.It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems,which has significant implications in disease processes as well.

关 键 词：Relative specificity Biochemical activity SUBSTRATES Biological systems 

分 类 号：Q78[生物学—分子生物学]