系统性红斑狼疮患者血清基质金属蛋白酶-9浓度变化的Meta分析  

Meta-analysis on serum concentration of MMP-9in systemic lupus erythematosus patients

作　　者：侯传云[1] 赵萍[1] 张源潮[2] 

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233004 [2]山东省立医院风湿免疫科,济南250012

出　　处：《检验医学与临床》2014年第5期618-620,共3页Laboratory Medicine and Clinic

摘　　要：目的对系统性红斑狼疮(SLE)患者血清基质金属蛋白酶-9(MMP-9)的浓度变化进行系统评价。方法使用循证医学文献分析方法,从CBM、CNKI、维普科技期刊数据库及Pubmed文献数据库中检索有关SLE患者血清MMP-9浓度的文献,使用Rev Man5.0软件进行Meta分析。结果共有7篇文献入选,Meta分析结果显示SLE患者血清MMP-9浓度与健康对照组相比差异无统计学意义(P>0.05)。结论血清MMP-9浓度不足以用作SLE协助诊断及疗效判断的指标。Objective To evaluate systemically the change of serum MMP-9 concentration in patients with systemic lupus erythematosus （SLE ） .Methods By literature analysis based on evidence-based medicine ,articles a-bout serum concentration of MMP-9 in SLE patients were obtained from data bases of Pubmed ,CBM ,CNKI and VIP .Results A total of seven literatures were selected and no difference was found between serum concentration of MMP-9 in SLE patients and that of healthy controls .Conclusion Serum concentration of MMP-9 should not be used as index for diagnosis and therapy in SLE .

关 键 词：系统性红斑狼疮 基质金属蛋白酶-9 M eta分析 MATRIX METALLOPROTEINASE 9 

分 类 号：R587.1[医药卫生—内分泌]