三种国产甲型肝炎减毒活疫苗的免疫学效果比较  

Comparative Study on the Immune Effects of Three Kinds of China made Live Attenuated Hepatitis A Vaccines

作　　者：张世勇[1] 刘新力[1] 丁月新[2] 夏建玲 侯通[1] 张勇[2] 

机构地区：[1]石家庄市卫生防疫站,河北石家庄050011 [2]河北医科大学,石家庄050017 [3]石家庄市郊区卫生防疫站,河北石家庄050081

出　　处：《中国计划免疫》2001年第1期38-39,共2页Chinese Journal of Vaccines and Immunization

摘　　要：为考核并比较甲型肝炎减毒活疫苗 (甲肝疫苗 )的免疫学效果 ,对 314名易感儿童随机分为 3组 ,分别接种市售昆明、杭州、长春 3个厂家生产的甲肝疫苗 ,免疫后 2 1、34天采血检测抗 -HAV。结果显示 :免疫后 2 1天 3个厂家甲肝疫苗抗 -HAV阳转率分别为 6 1 9%、6 0 9%和 80 0 % ,免疫后 34天分别为 71 6 %、6 6 7%和 44 9% ,国产高滴度甲肝疫苗安全性好 ,但疫苗质量有待进一步提高 。To evaluate and compare the immune effects of three kinds of domestic live attenuated hepatits A vaccines, 314 anti hepatitis A virus(HAV)antibody negative children were randomly divided into 3 groups and vaccinated with commercial live attenuated hepatitis A vaccines made in Kunming, Hangzhou and Changchun respectively. Serum samples collected 21 and 34 days after inoculation were tested for anti HAV. The vaccines produced in 3 factories all had a similar positive seroconversion rates of 61.9%, 60.9% and 80.0% 21 days after, vaccination and a significantly differential rates of 71.6%, 66.7% and 44.9% 34 days after. The results suggested that China made live attenuated hepatits A vaccine with higher titer is safe, but the quality need to be improved to get a better immune efficacy.

关 键 词：甲型肝炎减毒活疫苗 免疫学 疫苗质量 

分 类 号：R512.610.1[医药卫生—内科学] R392-33[医药卫生—临床医学]