噁丙嗪分散片的研制及溶出度  

Study of oxaprozin dispersible tablets and comparison on its dissolution

作　　者：陈鹰[1] 盛莉[1] 高武保 宋琪[1] 汤韧[1] 

机构地区：[1]广州军区武汉总医院,湖北武汉430070

出　　处：《中国医院药学杂志》2001年第2期82-84,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :制备卟恶丙嗪分散片 ,并将其与另两种市售片剂的溶出度进行比较。方法 :通过实验获得处方和工艺 ,制定质量标准和溶出度测定方法 ,并对其进行质量评价和溶出度比较。结果 :本品完全符合英国药典中有关分散片的要求 ,其溶出参数 (m =0 .5 7,t50 =0 .5 1min ,td=0 .97min)与另两种市售片剂间差异存在极显著性。结论 :卟恶丙嗪分散片比另两种市售片剂崩解快、分散均匀度好、溶出快而完全。OBJECTIVE:To prepare oxaprozin dispersible tablets,and the dissolution rate of it was compared with the other two commericial tablets. METHODS:The oxaprozin dispersible tablet was prepared . Also estimate of its quality and comparison on dissolution were carried out. RESULTS:The preparation completely conformed to the quality standard for dispersible tablet stated in the british pharmacopoeia.The parameters of dissolution between oxaprozin dispersible tablets and the other two commericial tablets were greatly significant. CONCLUSIONS:The oxaprozin dispersible tablets was characteristic of rapid disintegration,uniform dispersion,fast and complete dissolution.It would be a new dosage form of developmental worth.

关 键 词：WU丙嗪分散片 制备 溶出度 质量标准 抗炎 镇痛 

分 类 号：R971.1[医药卫生—药品] R927.11[医药卫生—药学]