龙血竭总酚提取物化学成分的分离鉴定  

Isolation and Structural Identification of Compounds from Total Phenols Extract of Dragon's Blood

作　　者：刘芳[1] 戴荣继[1] 吕芳[1] 孟薇薇[1] 陈艳 邓玉林[1] 

机构地区：[1]北京理工大学生命学院,北京100081 [2]北京理工亘元医药技术开发中心有限公司,北京100081

出　　处：《北京理工大学学报》2014年第1期102-105,共4页Transactions of Beijing Institute of Technology

基　　金：国家教育部高等学校博士学科点专项科研基金(新教师课题基金)资助课题(20091101120045)

摘　　要：运用聚酰胺、硅胶、葡聚糖凝胶等柱色谱方法,从云南产龙血竭总酚提取物中分离出4个黄烷类、2个芪类、4个甾体类成分.通过现代波谱学方法结合化学显色方法,鉴定其结构分别是4′,7-二羟基黄烷;7-羟基-4′-甲氧基黄烷;4′,7-二羟基-3′-甲氧基-8-甲基黄烷;4′,7-二羟基高异黄烷;4′-羟基-3,5-二甲氧基二苯乙烯;反式-4′,5-二羟基-3-甲氧基-二苯乙烯;豆甾醇;4-甲基-胆甾-7-烯-3β-醇;环阿尔廷醇;25(R)-薯蓣皂苷元.化合物4′,7-二羟基-3′-甲氧基-8-甲基黄烷、反式-4′,5-二羟基-3-甲氧基-二苯乙烯、环阿尔廷醇、25(R)-薯蓣皂苷元为首次从龙血竭中分离得到.Using various chromatographic techniques including column chromatography of silica gel, polyamide and Sephadex-LH20, four flavanes, two stilbenes and four steroids are isolated from the total phenols extract of dragon＇s blood. These compounds are identified by analyzing the chemical characters and spectroscopic data of the ^1H NMR, nC NMR and MS. They are 4＇,7- dihydroxyflavane, 7 hydroxy-4＇-methoxyflavane, 4＇, 7-dihydroxy-3＇-methoxy-8-methylflavane, 4＇, 7-dihydroxyhomoisoflavane, pterostilbene, trans-4＇, 5-dihydroxy-3-methoxy diphenyhhene, stigmasterol, 4-methyl-cholesta-7-ene-3β-ol, cycloartanol and diosgenin. Among them, 4r, 7- dihydroxy-3＇-methoxy-8-methylflavane, trans-4~, 5-dihydroxy-3-methoxy-diphenylethene, cycloartanol and 25 （R）-diosgenin are isolated from the resin of Dracaena Co. chinchinensis （Lout.）S. C. Chen for the first time.

关 键 词：龙血竭 化学成分 黄烷 芪类 甾体 

分 类 号：R284[医药卫生—中药学]