防御素和cathelicidins／LL-37在肺部抗感染防御中的研究现状  

Research status of defensins and cathelicidins/LL-37 in pulmonary anti-infection immune defense

作　　者：郭书真 李昌崇[1] 林立[1] 

机构地区：[1]温州医科大学附属育英儿童医院呼吸科浙江省小儿呼吸系统疾病诊疗研究中心,325027

出　　处：《国际呼吸杂志》2014年第4期290-293,共4页International Journal of Respiration

基　　金：浙江省自然科学基金重点项目（LZ13H010001）

摘　　要：抗菌肽是宿主防御系统的重要组成部分。在人气道上皮中主要表达2种阳离子小分子抗菌肽，即防御素和cathelicidins／LL-37，它们通过直接杀菌、调节天然或适应性免疫、损伤修复等生物学活性对抗肺部常见病原体的侵袭。本文就防御素和cathelicidins／LL-37的来源及结构特征、表达调节、在肺部抗感染免疫防御中的作用进行综述。Antimicrobial protein/peptides（AMPs） are an important part of the defense system. Defensins and cathelicidins/LL-37 are the two main small cationic AMPs which are present in airway epithelial cells. AMPs play a critical role in resisting pathongens of invading lung through direct antimicrobial activity, modulating innate or adaptive immunity, and wound repair. The orign and architectural feature, expression regulation and research progress in pulmonary anti-infection immune defense of defensins and cathelicidins/LL-37 are reviewed here.

关 键 词：防御素 CATHELICIDINS LL-37 病原体 天然免疫 

分 类 号：R563[医药卫生—呼吸系统]