Caveolin-1在支气管哮喘中的研究进展  

Research progress of caveolin-1 in bronchial asthma

作　　者：戴威[1] 王瑞丽[2] 戴元荣[2] 

机构地区：[1]温州医科大学第二临床学院,325027 [2]温州医科大学附属第二医院呼吸内科,325027

出　　处：《国际呼吸杂志》2014年第5期360-363,共4页International Journal of Respiration

基　　金：浙江省卫生厅资助项目（2009A144）

摘　　要：微囊（caveolae）是存在于细胞膜上烧瓶样的内陷微结构，它参与细胞的众多生命活动，如细胞的内吞作用、胆固醇代谢、肿瘤的发生以及信号转导过程。微囊蛋白-1（caveolin-1）是caveolae最重要的结构蛋白，研究表明许多呼吸系统疾病与caveolin-1的表达异常密切相关，本文就其在支气管哮喘中的研究进展作一综述。Caveolae are micro structures which form flask-shaped invaginations of the plasma membrane, caveolae are involved in many life activities of the cells, such as endocytosis, cholesterol metabolism, tumorigenesis and the process of signal transduction. Caveolin-1 is the most important structural protein of caveolae,studies have shown that many respiratory diseases is closely related to the abnormal of caveolin-1. Here,we introduce the research progress of caveoliwl in bronchial asthma.

关 键 词：微囊 微囊蛋白-1 支气管哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]