中性粒细胞凋亡延迟与重叠综合征患者的氧化应激和系统性炎症  

Delayed apoptosis of neutrophile and the oxidative stress and systemic inflammation of respiratory overlap syndrome

作　　者：高梦丽[1] 曹洁[1] 冯靖[1] 陈宝元[1] 

机构地区：[1]天津医科大学总医院呼吸科,300052

出　　处：《国际呼吸杂志》2014年第5期395-400,共6页International Journal of Respiration

基　　金：国家自然科学基金资助（8]270144、30800507、81170071）

摘　　要：呼吸重叠综合征简称重叠综合征（OS）通常是指阻塞性睡眠呼吸暂停（OSA）和COPD的共患，其较单纯COPD或OSA存在更明显的低氧血症的发生，并且心血管并发症的发生率和病死率也明显增加。本文综述了OS导致氧化应激和系统性炎症的可能机制以及中性粒细胞凋亡延迟相关的调节机制。Respiratory overlap syndrome, for short overlap syndrome （OS）,is commonly used to describe the coexisting of chronic obstructive pulmonary disease （COPD） and obstructive sleep apnea （OSA）. OS develop more pronounced hypoxemia than COPD or OSA alone, and the morbidity and mortality of cardiovascular comorbidities is also higher in OS. This paper summarized the mechanism of oxidative stress and systemic inflammation attributing to OS and the regulating mechanism in the delayed apoptosis of neutrophile.

关 键 词：呼吸重叠综合征 慢性阻塞性肺疾病 阻塞性睡眠呼吸暂停 氧化应激 炎症 中性粒细 胞 凋亡 

分 类 号：R563.9[医药卫生—呼吸系统]