空洞型耐多药肺结核患者耐药性分析及治疗方案探索  

Drug resistance analysis and treatment explortion in patients with multi-drug resistant cavity tuberculosis

作　　者：何小珊[1] 邓丽红[1] 朱辉超[1] 郭俊华[1] 

机构地区：[1]梅州市人民医院感染科,514000

出　　处：《中国现代药物应用》2014年第3期1-3,共3页Chinese Journal of Modern Drug Application

基　　金：广东省梅州市课题(项目编号:2013-B-22)

摘　　要：目的探讨耐多药肺结核患者耐药性产生原因及治疗方法。方法对2012年10月～2013年10月间,本院收治的68例空洞型耐多药肺结核患者耐药性进行分析,并探讨治疗方法。结果本次调研发现,患者治疗依从性差,是导致多重耐药肺结核的因素,其次,治疗方法的不合理同样导致患者感染,因此针对患者采用个性化的治疗是治疗耐多药肺结核患者的重要手段,本次实验中,观察组患者使用个性化的耐药菌敏感药物进行治疗,治疗效果优于对照组(χ2=4.239,P=0.036<0.05)。结论导致患者耐多药感染的主要因素是由于治疗依从性差及治疗方案的不合理,因此对患者进行教育和心理疏导以及个体化全面治疗,有助于耐多药肺结核治疗。Objective To study the causes of patients with multi-drug resistant pulmonary tuberculosis and find appropriate treatment methods. Methods From October 2012 to October 2013, Hospital treating 68 cases of cavitary patients with MDR-TB drug resistance analysis, the reasons of drug-resistant bacteria infected was analyzed in order to given a personalized antibacterial treatment for the patients. Results Results showed that the main reason of multiple drug resistant tuberculosis infection is the low compliance of treatment in patients. Secondly, unreasonable treatment also cause infection. So for patients with personalized treatment is an important means of treatment of multiple drug-resistant TB, this experiment, the observation group of patients using personalized drug-resistant bacteria sensitive drug treatment, the treatment effect is better than the control group （P〈O.05）. Conclusion For patients with multiple drug-resistant infection is the main factor due to poor treatment adherence and unreasonable treatment, so the patient education and psychological counseling and individualized comprehensive treatment, help more drug-resistant tuberculosis treatment.

关 键 词：耐多药肺结核 空洞型 治疗方案 

分 类 号：R521[医药卫生—内科学]