类风湿Ⅰ号丸增加高度活动类风湿关节炎脾气亏虚、湿热阻络证疗效的临床观察  

Clinical Observation of RheumatoidⅠDrug Increasing Curative Effect in Treating Highly Active Rheumatoid Inflammation

作　　者：任璇璇[1] 宋欣伟[2] 郑燕[3] 关天容[2] 戴巧定[2] 张彦[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江省中医院,浙江杭州310053 [3]杭州市第六人民医院,浙江杭州310000

出　　处：《中华中医药学刊》2014年第3期578-581,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2007GA016)

摘　　要：目的:通过规范的临床研究,系统观察类风湿Ⅰ号丸联合免疫抑制剂甲氨蝶呤(MTX)、来氟米特(LEF)、雷公藤多苷片(TWP)对高度活动类风湿关节炎脾气亏虚、湿热阻络证的治疗,评估临床疗效。方法:将138例高度活动类风湿关节炎,中医辨证为脾气亏虚、湿热阻络证患者随机分为两组,两组均口服同剂量、同疗程MTX、LEF、TWP,治疗组加服类风湿Ⅰ号丸,观察两组治疗后各项疗效评价指标的改善情况,并记录不良反应。结果:治疗24周后两组均有明显疗效,但治疗组左右手握力、关节疼痛数、关节肿胀数、受试者疼痛VAS评分、研究者疾病总体状况VAS评分及RF优于对照组(P<0.05);治疗组晨僵时间,ESR、CRP、CCP,ACR50、ACR70及DAS28有效率明显优于对照组(P<0.01)。结论:类风湿Ⅰ号丸联合MTX、LEF、TWP对高度活动类风湿关节炎有显著疗效,可迅速缓解症状,改善炎症指标。Objective： To systematically evaluate and compare the therapeutic efficacy of Rheumatoid I combined with MTX, LEF and TWP in treating highly active rheumatoid iifflammation （phlegm resistance of spleen insufficiency, damp - heat stagnation in meridian syndrome of Bi disease） by standard clinical research so as to evaluate the clinical effect. Methods： All of the 138 highly active rheumatoid patients were randomly divided into different groups. All patients took the same dose and coupe MTX,LEF and TWP while the treating group combined with Rheumatoid I. Signs and symp- toms and chemical examination result and adverse effect were observed after treatment. Resuhs：After 24 weeks treatment, both groups got obvious curative effect. The grip stl^ngth, the numbers of pain and swell joint, patients VAS score with pain,research VAS score and RF in the treatment group were much better than those in the control group （ P 〈 0.05）. The treatment group was superior to the control group in terms of duration of morning stiffness, ESR, CRP, CCP and the improvement of ACR20,ACRS0 and DAS28 efficacy judgment（ P 〈 0. 01 ）. Conclusion： Rheumatoid I combined with MTX, LEF and TWP can significantly improve the clinical symptoms and laboratory of patients with highly active rheuma- toid arthritis.

关 键 词：高度活动类风湿关节炎 类风湿I号丸 DAS28积分 

分 类 号：R593.22[医药卫生—内科学]