动物黏膜免疫佐剂研究新进展  

Advances of Mucosal Adjuvant of Animal

作　　者：胡桂学[1] 徐浩[1] 郭慧[1] 陈中秋 

机构地区：[1]吉林农业大学动物科学技术学院,长春130118 [2]辽宁成大生物股份有限公司,沈阳110179

出　　处：《经济动物学报》2014年第1期1-4,10,共5页Journal of Economic Animal

基　　金：吉林省重大科技攻关项目(09ZDGG008)

摘　　要：黏膜佐剂可提高疫苗的免疫原性,延长抗原与黏膜及免疫活性细胞的作用时间,减少黏膜免疫耐受,增强疫苗免疫效果。本文主要综述了细菌脂肽、polyI:C和单磷酰类脂A等Toll样受体配体佐剂,芽胞、脂质体和纳米乳等黏膜传递系统以及其他新型黏膜佐剂的研究新进展,展望了黏膜佐剂在免疫学上的应用前景。The ability of mucosal adjuvant is to increase the immunogenicity of the vaccines, to extend the duration of interactions between the antigen and mueosal immune activity cells, to reduce the mucosal immune tolerance of antigen thus improving immune effects of vaccines. In this article the recent advances of Toll-like receptor ligands including Baeterial lipopeptides, polyI： C and monophosphoryl lipid A, deliv- ery systems of mueosal vaccines such as spore, liposome and nanoemulsion, and some new mueosal adju- vants were reviewed to provide some immunological prospects of mucasal adjuvant.

关 键 词：黏膜 佐剂 TOLL样受体 黏膜传递系统 

分 类 号：S852.4[农业科学—基础兽医学]