非选择性一维氢磷相关技术及其在含磷化学毒剂相关化合物分析中的应用  

Application of Nonselective ~1H-^(31)P Heteronuclear Coherence Technique in Detection of Organophosphorous Chemical Warfare Agent Related Compounds

作　　者：钟近艺[1,2] 郑禾[2] 崔燕[2] 

机构地区：[1]国民核生化灾害防护国家重点实验室,北京102205 [2]防化研究院,北京102205

出　　处：《分析测试学报》2014年第3期344-348,共5页Journal of Instrumental Analysis

基　　金：国家自然科学基金青年基金资助项目(21207160)

摘　　要：以异核单量子相关(HSQC)、异核多量子相关(HMQC)核磁共振理论为基础,实现了一维非选择性1H-31P HSQC、1H-31P异核单量子结合多键相关(HSQMBC)脉冲序列,并自主设计了一维非选择性1H-31P HMQC脉冲序列,研究了3种技术在峰形、灵敏度上的差异。通过对某次国际禁化武组织水平考试的水样分析发现,非选择性1H-31P HMQC方法是目前用于筛选含磷化学毒剂相关化合物的最有效方法。Based on the theories of heteronuclear single quantum coherence （HSQC） and heteronucle- ar multiple quantum coherence （HMQC）, 1D nonselective 1H -31p HSQC, heteronuclear single quantum coherence and multiple bond correlation （HSQMBC）were applied and I D nonselective 1H _ 31p HMQC pulse sequences were designed for screening the organophosphorous （OP） com- pounds. The differences among these methods were studied, especially in peak shape and sensitivi- ty. From results of the analysis on the OP compounds in the OPCW proficiency test, 1 D nonselective HMQC method has been proved to be the most effective and sensitive in NMR experiments so far.

关 键 词：氢磷相关 核磁共振 有机磷化合物 

分 类 号：O482.532[理学—固体物理] O623.627[理学—物理]