阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者血清内脂素和脂联素检测的临床意义  

The clinical significance of serum visfatin and adiponectin in patients with obstructive sleep apnea-hypopnea syndrome combined with type 2 diabetes mellitus

作　　者：徐梅华[1] 袁勇谋 蔡克银[1] 

机构地区：[1]广州军区武汉总医院干部病房二科,湖北省武汉430070 [2]武汉市皮肤病防治研究所

出　　处：《中国慢性病预防与控制》2014年第1期16-18,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并2型糖尿病(T2DM)患者血清内脂素、脂联素水平的变化及其临床意义。方法选择OSAHS合并T2DM患者135例(根据睡眠呼吸暂停低通气指数分为轻度、中度、重度组,分别为40、39、56例)及单纯OSAHS患者62例、单纯T2DM 69例、对照组20例作为研究对象,采用酶联免疫吸附法(ELISA)检测各组血清内脂素、脂联素水平。结果单纯OSAHS组、单纯T2DM组及对照组血清内脂素水平分别为(32.46±6.53)、(29.38±5.70)和(18.74±3.37)ng/ml,血清脂联素水平分别为(7.98±3.74)、(7.65±3.11)和(13.43±2.04)mg/L,与上述3组比较,OSAHS合并T2DM组血清内脂素水平[(46.32±6.21)ng/ml]明显升高,血清脂联素水平[(4.61±2.33)mg/L]明显降低,差异均有统计学意义(P<0.05,P<0.01)。OSAHS合并T2DM患者中,睡眠呼吸暂停低通气指数重度组患者血清内脂素水平[(54.32±7.19)ng/ml]明显高于中度组[(45.24±6.56)ng/ml],中度组明显高于轻度组[(31.41±4.31)ng/ml],差异均有统计学意义(P<0.01);重度组血清脂联素含量[(2.94±2.33)mg/L]明显低于中度组[(4.76±2.61)mg/L],中度组明显低于轻度组[(6.98±2.12)mg/L],差异均有统计学意义(P<0.01)。结论内脂素、脂联素可能参与了OSAHS合并T2DM的发生、发展。OSAHS合并T2DM患者血清内脂素、脂联素水平与睡眠呼吸暂停低通气指数密切相关。Objective To explore the changes and clinical significance of serum visfatin and adiponectin in patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） combined with type 2 diabetes mellitus （T2DM）. Methods The subjects of present study included 62 patients with OSAHS, 69 patients with T2DM, 20 healthy controls and 135 patients with OSAHS combined with T2DM, who were divided into mild, moderate and severe groups according to apnea-hypopnea index. Serum visfatin and adiponectin levels of all subjects were examined by ELISA. Results Serum level of visfatin [（46.32±6.21 ） ng/ml] in patients with OSAHS combined with T2DM was significantly higher than those [（32.46±6.53）, （29.38 ±5.70） and （18.74±3.37） ng/ml] in patients with OSAHS, patients with T2DM and controls （P〈0.05, P〈0.01 ）. Serum level of adiponeetin [（4.61±2.33 ） mg/L] in patients with OSAHS combined with T2DM was significantly lower than those [（7.98±3.74）, （7.65±3.11 ） and （13.43±2.04） mg/L] in patients with OSAHS, patients with T2DM and controls （P〈0.05, P〈0.01 ）. In patients with OSAHS combined with T2DM, the serum level of visfatin [（54.32±7.19） ng/ml] in severe group was significantly higher than that [（45.24±6.56） ng/ml] in moderate group, also which was higher than that [（31.41±4.31 ） ng/ml] in mild group （P〈0.01）; the serum level of adiponectin [（2.94±2.33 ） rag/L] in severe group was significantly lower than that [（4.76±2.61 ） mg/L] in moderate group, also which was lower than that [（6.98±2.12） mg/L] in mild group （P〈0.01）. Conclusion The visfatin and adiponeetin may play a role in development of OSAHS combined with T2DM. The serum levels of visfatin and adiponectin may be correlated with apnea-hypopnea index in patients with OSAHS combined with T2DM.

关 键 词：睡眠呼吸暂停 阻塞性 糖尿病 内脂素 脂联素 

分 类 号：R563.9[医药卫生—呼吸系统]