螺内酯治疗无症状左心室收缩功能障碍伴室性心律失常患者的临床观察  

CLINICAL OBSERVATION OF SPIRONOLACTONE TREATMENT OF PATIENTS WITH ASYMPTOMATIC LEFT VENTRICULAR SYSTOLIC DYSFUNCTION AND VENTRICULAR ARRHYTHMIA

作　　者：戴士鹏[1] 李瑞霞[2] 耿涛[1] 张建刚[1] 胡秀钦[1] 徐泽升[1] 

机构地区：[1]河北省沧州市中心医院心内二科,河北沧州061001 [2]河北省沧州市中心医院二门诊,河北沧州061001

出　　处：《河北医科大学学报》2014年第1期6-9,共4页Journal of Hebei Medical University

摘　　要：目的探讨螺内酯对无症状左心室收缩功能障碍伴室性心律失常患者室性心律失常的影响。方法入选门诊及住院无症状左心室收缩功能障碍(左心室射血分数<50%,左心室舒张末期容积指数>75mL/m^2,纽约心脏病协会心功能分级Ⅰ级)伴室性心律失常患者101例,在常规治疗的基础上随机分为螺内酯干预组51例(螺内酯30mg/d),对照组50例,所有患者在入选前及药物应用6个月后行24h动态心电图检查,评估室性期前收缩和非持续性室性心动过速的变化。结果治疗6个月时,螺内酯组室性期前收缩及非持续性室性心动过速明显减少且差异有统计学意义(P<0.05);对照组变化不明显。结论在常规治疗的基础上加用螺内酯治疗可减少无症状左心室收缩功能障碍伴室性心律失常患者室性心律失常的发生。Objective The study was to investigate the effect of spironolactone to ventricular arrhythmia in patients with asymptomatic left ventricular systolic dysfunction and ventricular arrhythmia. Methods There were 101 patients with asymptomatic left ventricular systolic dysfunction （left ventricular ejection fraction 〈 50%, left ventricular end diastolic volume index 〉 75mL/m^2, New York Heart Association class I ） and ventricular arrhythmia were enrolled in Cangzhou Central Hospital from December of 2008 to June of 2011. Spironolactone 30mg/d was randomly administered in addition to the routine treatment for 51 patients. All the patients were examined 24 hours dynamic electrocardiogram to assess the change of ventricular premature beat and nonsustained ventricular tachycardia before treatment and 6 months after treatment. Results In six months after treatment, ventricular premature beat and nonsustained ventricular tachycardia were reduced obviously in spironolactone group （ P 〈 0.05 ）, while the changes in control group were not significant. Conclusion Spironolactone was adminstered in addition to the routine treatment for patients with asymptomatic left ventricular systolic dysfunction and ventricular arrhythmia to reduce ventricular arrhythmia.

关 键 词：心力衰竭 充血性 螺内酯 心律失常 

分 类 号：R541.61[医药卫生—心血管疾病]