Design,synthesis and insecticidal activity of spiro heterocycle containing neonicotinoid analogs  

作　　者：Nan-Yang Chen Li-Ping Ren Min-Ming Zou Zhi-Ping Xu Xu-Sheng Shao Xiao-Yong Xu Zhong Li 

机构地区：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology

出　　处：《Chinese Chemical Letters》2014年第2期197-200,共4页中国化学快报（英文版）

基　　金：financial supported by National Basic Research Program of China(973 Program,No.2010CB126100);National High Technology Research Development Program of China(863 Program,No.2011AA10A207);Key Projects in the National Science & Technology Pillar Program(No.2011BAE06B05);National Natural Science Foundation of China(No.21372079);Shanghai Education Committee(No.12ZZ057);the Fundamental Research Funds for the Central Universities;partly supported by Australia DC Foundation

摘　　要：Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenone framework were designed and synthesized. Insecticidal evaluation showed that some of spirobenzofuranone containing neonicotinoids exhibited moderate activity against cowpea aphid, armyworm or brown planthopper.Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenone framework were designed and synthesized. Insecticidal evaluation showed that some of spirobenzofuranone containing neonicotinoids exhibited moderate activity against cowpea aphid, armyworm or brown planthopper.

关 键 词：NEONICOTINOID Spiro heterocycle Activity INSECTICIDE 

分 类 号：TQ453[化学工程—农药化工]