痢疾疫苗研究近展  

Recent progress towards development of a Shigella vaccine

作　　者：董岩(综述)[1] 曾明(综述)[1] 

机构地区：[1]中国食品药品检定研究院肠道细菌疫苗室,北京100050

出　　处：《国际生物制品学杂志》2014年第1期15-18,共4页International Journal of Biologicals

摘　　要：痢疾是全世界范围内流行的肠道传染病,由志贺菌属细菌引起.由于对志贺菌的致病机制和机体抗感染免疫还不十分了解,目前尚无有效的市售痢疾疫苗.此文讨论了志贺菌的致病机制,对痢疾疫苗研究的近展进行了综述,尤其是亚单位疫苗.Dysentery is a worldwide epidemic of infectious disease caused by the Shigella.Because the pathogenesis of Shigella and body immunity against infection are not very clear,there is no real practical Shigella vaccine on the market for now.This review discusses the pathogenesis of Shigella,and provides the latest developments in Shigella vaccines research,especially in subunit vaccines.

关 键 词：痢疾志贺菌 疫苗 亚单位 佐剂 免疫 

分 类 号：R392.7[医药卫生—免疫学]