参与病毒裂解性复制周期的人巨细胞病毒皮层蛋白  

Tegument proteins involved in lytic replication cycle of human cytomegalovirus

作　　者：张文昌(综述)[1] 甘霖(审校)[1] 陈敬贤(审校)[2] 王明丽(审校)[1] 

机构地区：[1]安徽医科大学微生物学教研室,合肥230032 [2]10032纽约,哥伦比亚大学病理与细胞生物学教研室

出　　处：《国际生物制品学杂志》2014年第1期19-23,共5页International Journal of Biologicals

基　　金：国家自然科学基金（30872253）;安徽省科技攻关计划（08010302179）

摘　　要：人巨细胞病毒（human cytomegalovirus,HCMV）是疱疹病毒科β亚科的成员,具有典型的疱疹病毒结构和基因表达模式.在核衣壳与包膜之间的皮层区域含有多种蛋白以及病毒或细胞的RNA,这些蛋白统称为皮层蛋白.皮层蛋白不仅占病毒颗粒蛋白的大部分,而且功能多样.此文就HCMV皮层蛋白在病毒入胞、基因表达、免疫逃避、组装和释放几个重要阶段中的功能做一综述.Human cytomegalovirus （HCMV） is a member of the Betaherpesvirinae sub-family of Herpesviridae family and has the classical herpesvirus structure and cascade of gene expression.Between the capsid and envelop is a layer called tegument,which is composed of many viral or cellular proteins and RNAs.The proteins are called tegument proteins.With multiple functions,tegument proteins also comprise majority of virion proteins.This review focuses on functional roles that tegument proteins play during HCMV infection,including viral entry,gene expression,immune evasion as well as assembly and release.

关 键 词：巨细胞病毒 皮层蛋白 基因表达 免疫逃逸 

分 类 号：R373[医药卫生—病原生物学]