妊娠相关血浆蛋白A基因IVS6+95多态性与急性心肌梗死的易感性  

Association of pregnancy-associated plasma protein-A gene IVS6+95 polymorphism with susceptibility of acute myocardial infarction

作　　者：何国平[1] 钱志宏 刘凤杰 戚传平[2] 许联红[2] 

机构地区：[1]江苏大学附属武进医院心内科,江苏常州213002 [2]江苏大学附属武进医院中心实验室

出　　处：《临床心血管病杂志》2014年第3期215-218,共4页Journal of Clinical Cardiology

基　　金：江苏大学临床医学科技发展基金项目(No:JLY20080065)

摘　　要：目的：探讨中国常武地区汉族人群妊娠相关血浆蛋白A（PAPP-A）基因IVS6＋95多态性与急性心肌梗死（AMI）易感性的关系。方法：AMI组308例，对照组（无冠状动脉狭窄的非冠心病者）213例，采用聚合酶链反应一限制性片段长度多态性方法分析PAPP-A基因IVS6＋95多态性。结果：AMI组和对照组PAPP—A基因IVS6＋95位点均检出GG、CG和CC3种基因型。单因素和多因素分析均未发现CG和CC基因型频率分布在两组之间有统计学差异。与对照组相比，AMI组的GG基因型（52．58％：43．51％，P=0．049）和G等位基因（73．71％：67．05％，P=0．024）频率分布均较低；经多因素Logistic回归分析显示，AMI组的GG基因型（OR=0．642，95％CI：0．428-0．962，P=0．032）和G等位基因（OR=0．677，95％CI：0．487～0．942，P=0．020）频率仍低于对照组。结论：在中国常武地区汉族人群中，AMI患者和无冠状动脉狭窄的非冠心病者均存在PAPP—A基因IVS6＋95多态性，且后者与AMI的易感性降低密切相关，提示GG基因型和G等位基因可能是减少AMI发病风险的遗传因素之一。Objective：To investigate the association of pregnancy-associated plasma protein-A （PAPP-A） gene IVS6 ＋ 95 polymorphism with susceptibility of acute myocardial infarction （AMI） in the Chinese Han population of Changwu region. Method： The 308 patients with AMI and 213 control subjects who were not coronary heart disease （CAD） without coronary artery stenosis by coronary angiography were recruited into the study. The PAPP-A gene IVS6 ＋ 95 polymorphism was measured by polymerase chain reaction and restriction fragment length polymor- phism. Result..GG, CG and CC genotype were detected in PAPP-A gene IVS6＋95 loci in AMI group and control group. Single factor and multi-factor analysis did not find that CG and CC genotype frequency distribution difference existed statistically between two groups. The frequencies of GG genotype （43.51% vs 52.58%, P=0. 049） and G allele （67.05% vs 73.71%, P=0. 024） in AMI group were lower than those in control group; Multiple logistic regression analysis showed that the frequencies of GG genotype （OR=0. 642, 95%CI：0. 428-0. 962, P=0. 032） and G allele （OR=0. 677, 95%CI： 0. 487-0. 942, P=0. 020） were still lower in AMI group than those in control group. Conclusion：The PAPP-A gene IVS6 ＋ 95 polymorphism exist in patients with AMI and non CAD subjects without coronary artery stenosis, and is closely related to reduce susceptibility of AMI, suggesting GG genotype and G allele may be one of genetic factor to reduced risk of AMI in the Chinese Han population of Changwu region.

关 键 词：急性心肌梗死 妊娠相关血浆蛋白A 基因多态性 

分 类 号：R542.2[医药卫生—心血管疾病]