肝门部胆管癌MR表现与病理、肿瘤血管生成的相关性研究  

Correlativity study of MRI features,pathology,and tumor angiogenesis in hilar cholangiocarcinoma

作　　者：矫娜[1] 马捷[1] 孙黎明[1] 钱立[1] 吴明祥[1] 凌人男[1] 

机构地区：[1]广东省深圳市人民医院放射科,广东深圳518000

出　　处：《医学影像学杂志》2014年第3期465-469,共5页Journal of Medical Imaging

摘　　要：目的探讨肝门部胆管癌MRI表现与病理、肿瘤血管生成之间的相关性。方法对28例肝门部胆管癌患者术前行MR扫描,分析MRI形态学特征、动态增强表现;术后标本行免疫组化染色测定病灶微血管密度(MVD)、血管内皮生长因子(VEGF)的表达情况,并分析其与MRI表现之间的相关性。结果侵袭转移(16例)组、病灶内胆管扩张(8例)组的MVD、VEGF表达明显高于无侵袭转移组、无病灶内胆管扩张组,且均具有统计学意义(P<0.05)。肿瘤生长方式的分型与MVD、VEGF表达无明显相关性(P>0.05)。MRI动态增强扫描中,不同强化形式组间的MVD值存在统计学差异(P<0.05),ΔSI(早期信号强度增强率)与MVD呈明显正相关,与VEGF的表达亦有相关性。结论肝门部胆管癌MRI表现与病理、肿瘤血管生成之间存在一定相关性,可根据其MRI表现对癌灶的生物学行为和预后进行评估。Objective To investigate the correlation among MRI features,pathology,and tumor angiogenesis of hilar cholangiocarcinoma.Methods MR scanning was performed in 28 patients with hilar cholangiocarcinoma before operation and MRI features of hilar cholangiocarcinoma were analyzed.The specimens of the hilar cholangiocarcinoma were stained with immunohistochemistry,the distribution of microvessel density （MVD） was measured.The results were compared with MRI features.Results MVD in the groups of invasion and metastases and biliary dilation in the lesions were higher than non-metastases and non-biliary dilation （P ＜0.05） ; but their relation to the morphologic classification according to growth pattern were not significant （P ＞0.05）.There was correlation between MVD and dynamic enhancement parttern （P ＜0.05） ; the enhancement rate （△SI） of the early-phase signal intensity was significantly correlated with MVD and VEGF.Conclusion There exists some correlation among MRI features,pathology,and tumor angiogenesis in hilar cholangiocarcinoma to certain extent.The biologic behavior and prognosis of hilar cholangiocarcinoma can be assessed according to MRI features.

关 键 词：肝门部胆管癌 磁共振成像 病理学 新生血管化 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]