乌司他丁对糖尿病肾脏疾病患者冠状动脉造影术后的肾保护作用  

Renal protective effects of ulinastatin in diabetic kidney disease patients after coronary angiography

作　　者：陈文莉[1] 曾星若[1] 陈刚[2] 

机构地区：[1]武汉市中心医院肾内科,武汉430014 [2]武汉市中心医院心内科,武汉430014

出　　处：《临床肾脏病杂志》2014年第2期82-85,共4页Journal Of Clinical Nephrology

基　　金：武汉市卫生局临床医学科研项目

摘　　要：目的 探讨乌司他丁对糖尿病肾脏疾病（diabetic kidney disease,DKD）患者冠状动脉造影术后的肾脏保护作用.方法 募集因反复心绞痛需行冠状动脉造影术的DKD患者43例,随机分为治疗组（n=23）和对照组（n=20）.从造影前12 h至造影后12h,2组均用0.9％氯化钠注射液静脉滴注水化,不同之处为治疗组自造影当天开始每日静滴乌司他丁20万单位,而对照组仅静滴0.9％氯化钠注射液100ml,疗程均为7d.分别于造影前及造影后1、3、7d留取2组患者的外周血标本,利用生化仪检测2组患者血肌酐（SCr）及血胱抑素C（Cys C）水平.结果 ①2组患者冠状动脉造影术后其外周血中SCr及Cys C的值均升高;②治疗组患者外周血中SCr及CysC于第3天及第7天升高幅度显著低于对照组（P＜0.05）,且差异有统计学意义.结论 乌司他丁能降低DKD患者行冠状动脉造影术后SCr及CysC升高幅度,具有肾脏保护作用.Objective To investigate the renal protective effects of ulinastatin in diabetic kidney disease patients after coronary angiography. Methods Forty-three cases of diabetic nephropathy were divided randomly into two groups： experimental group （n = 23） and control group （n = 20）. All pa- tients were subjected to coronary angiography because of intractable angina. The patients in both two groups were intravenously dripped with normal saline for hydration from 12 h before coronary angiog- raphy to 12 h after coronary angiography. The experimental group was given ulinastatin of 2. 0 105 U every day after coronary angiography, and the control group was given normal saline. Treatment peri- od was 7 days. The serum creatinine （SCr） and cystatin C （Cys C） levels were determined before and at day 1, 3 and 7 after coronary angiography. Results （I） SCr and Cys C levels in two groups were both increased after coronary angiography; （1） The increased extent of SCr and Cys C in experiment group was significantly lower than in control group （P0. 05）. Conclusions Ulinastatin can more ef- fectively decrease levels of SCr and Cys C in diabetic kidney disease patients after coronary angiography and play the role of protecting the kidney.

关 键 词：乌司他丁 糖尿病肾病 冠状动脉造影术 肾脏保护 

分 类 号：R654.2[医药卫生—外科学]