针刺治疗阿尔茨海默病实验模型的机制研究  

Progress of Experimental Research on Treating Alzheimer's Disease by Acupuncture

作　　者：刘宇婧[1] 付于[2] 

机构地区：[1]天津中医药大学研究生院,天津300073 [2]天津中医药大学第一附属医院针灸科,天津300073

出　　处：《中国中西医结合杂志》2014年第3期359-361,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金面上项目(No.81173414);天津市高校科技发展项目(No.20090220);高等学校博士学科点专项科研基金项目(No.20101210120006)

摘　　要：为探讨阿尔茨海默病的发病机制,通过总结近几年有关针刺治疗阿尔茨海默病(AD)动物模型发现,减少β-淀粉样蛋白产生,减轻tau蛋白过度磷酸化,调节中枢神经递质代谢障碍,抗自由基氧化,减少皮质、海马区神经元凋亡,抑制神经胶质细胞分化,调节G蛋白信号传导,改善线粒体功能障碍等可改善老年痴呆鼠的认知记忆能力确有改善,为针刺治疗老年痴呆病提供了实验依据。To discuss the pathogenesis of Alzheimer＇s disease （AD）, we summarized the mech- anisms of treating AD animal models by acupuncture from literatures in recent years as follows. Senile dementia rats＇ cognitive capabilities and memory could be improved by reduction of 13-amyloid protein, attenuation of excessive phosphorylation of tau protein, regulation of center neurotransmitter dysme- tabolism, oxidation of anti-free radicals, reduction of neuron apoptosis in the cortex and the hippocam- pus, inhibition of glial cells＇ differentiation, adjustment of G protein signaling transduction,and improve- ment of the mitochondrial dysfunction, thus providing experimental evidence for treating AD by acupunc- ture.

关 键 词：阿尔茨海默病 针刺治疗 动物模型 

分 类 号：R245[医药卫生—针灸推拿学]