全血γ干扰素释放试验在儿童和成人中的结核病诊断价值  

Evaluation of a whole-blood interferon γ release assay for the diagnosis of tuberculosis in children and adults

作　　者：鲍磊[1] 李涛[2] 卢水华[2] 

机构地区：[1]复旦大学附属华山医院感染科,上海200040 [2]上海市公共卫生临床中心,上海201508

出　　处：《微生物与感染》2014年第1期21-27,共7页Journal of Microbes and Infections

基　　金："十二五"国家科技重大专项(2013ZX10003001-002)

摘　　要：为研究全血γ干扰素释放试验试剂盒QuantiFERON-TB Gold In-Tube(QFT-GIT)在中国(属结核病高发、卡介苗高接种地区)成人和儿童中的结核病诊断价值,入组临床怀疑结核病的儿童和成人患者各60例,进行QFT-GIT检测,并收集临床资料进行诊断分类。结果显示,在儿童中QFT-GIT诊断灵敏度为83.87%、特异度为92.00%、阳性预测值(PPV)为92.86%、阴性预测值(NPV)为82.14%;在成人中诊断灵敏度为78.57%、特异度为84.62%、PPV为84.62%、NPV为78.57%。结果证实QFT-GIT具有良好的结核病诊断价值,尤其在儿童中的诊断价值高于成人。In order to evaluate the diagnostic value of the whole-blood interferon γ release assay kit QuantiFERON-TB Gold In-Tube （QFT-GIT ） in diagnosis of tuberculosis in children and adults in China （with a high rate of bacillus Calmette-Guérin vaccination and a high incidence of tuberculosis ） ,60 children and 60 adults with suspected tuberculosis were recruited for QFT-GIT test and clinical information collection . The results showed that among children , the sensitivity of QFT-GIT test was 83 .87% , the specificity was 92 .00% ,positive predictive value （PPV） was 92 .86% ,and negative predictive value （NPV） was 82 .14% . While among adults , the sensitivity of QFT-GIT test was 78 .57% , the specificity was 84 .62% ,PPV was 84 .62% ,and NPV was 78 .57% .Here comes a conclusion that QFT-GIT is of clinical value in diagnosis of tuberculosis ,especially among children .

关 键 词：酶联免疫吸附试验 儿童 成人 结核分枝杆菌 Γ干扰素释放试验 

分 类 号：R52[医药卫生—内科学]