64层螺旋CT在冠状动脉粥样斑块药物治疗随访中的价值  

Application value of 64-slice spiral CT coronary angiography in the follow-up of coronary artery disease patients with conservative medical management

作　　者：陈秀斌[1] 邵广瑞[1] 仲海[1] 赵永[1] 

机构地区：[1]山东大学第二医院影像科,山东济南250033

出　　处：《实用放射学杂志》2014年第3期421-424,433,共5页Journal of Practical Radiology

基　　金：山东省国际科技合作项目（2010-6）.

摘　　要：目的 评价64层螺旋CT冠状动脉成像（64SCTCA）在冠状动脉粥样斑块药物治疗随访中的应用价值。方法 收集12例采用内科保守治疗的冠心病患者,先后行2次64层冠状动脉CTA检查，2次检查间隔6~12个月，测量前后2次21处非钙化斑块和以非钙化成分为主的混合斑块的体积及管腔狭窄程度,用配对t检验并分别进行统计学分析。结果 21处斑块前后2次检查总体积分别为3 450.63 mm3、3 036.96 mm3，平均体积分别为（164.32±55.61） mm3、（144.62±48.24）mm3，平均狭窄程度分别为（62.90±10.15）%、（50.72±10.13）%，经内科保守治疗6~12个月后斑块负荷降低，且前后2次检查间的斑块体积及狭窄程度差异均有统计学意义（t=2.95，P〈0.01；t=3.96，P〈0.05）。结论 内科药物治疗可有效控制冠心病患者病情的进展，并可以降低冠状动脉非钙化斑块的负荷。64层螺旋CT在冠状动脉斑块的随访中有重要的应用价值。Objective To investigate the value of 64-slice spiral computed CT coronary angiography（64SCTCA） in the follow-up on palients received eouservative medical management. Methods 12 patients with coronary artery disease who accepted conservative medical management were enrolled in our study. Each patient underwent twice 64SCTCA whh 6--12 months intervals, and the vof ume and degree of coronary artery stenosis of each plaque were measured and analyzed using paired ttest, respectively. The plaques included nonLcalcified plaques and mixedLplaques with more non calcified component and the total was 21. Results The total volumes of 21 plaques of two results were 3 450. 63 mm3 and 3 036.96 mm3, the average volumes were （164.32±55.61） mm3 and （ 144.62±48.24}mm3 ,respectively,and the average degree of stenosis were{62.90±10. 15）% and（50.72±10. 13}%, respectively. After the 6-12 months＇conservative medical management, the atherosclerotic plague burden was reduced, and the difference of each paired t test group was significant { t=2.95, P〈0.01 ;t = 3.96, P〈0.05 ）. Conclusion Conservative medical management can effec- lively control the progress of coronary artery disease and reduce the non-calcified plaque burden. MSCT coronary angiography is val uable in following up coronary plaque.

关 键 词：冠状动脉疾病 计算机体层成像 钙质沉着症 

分 类 号：R543.3[医药卫生—心血管疾病] R814.42[医药卫生—内科学]