女性术后吗啡静脉镇痛泵中加入昂丹司琼不能减少术后恶心呕吐  

Ondansetron added to intravenous morphine analgesia pump could not reduce postoperative nausea and vomiting in female patients

作　　者：裴丽坚[1] 桑诺尔[1] 高鲜丽 夏伟鹏 任立英 李虹[1] 张秀华[1] 黄宇光[1] 

机构地区：[1]中国医学科学院北京协和医院麻醉科,北京100730 [2]深圳市卫生局,广东深圳518020 [3]中国医学科学院整形外科医院麻醉科,北京100041 [4]中国医学科学院北京协和医院麻醉科手术室,北京100730

出　　处：《基础医学与临床》2014年第4期519-522,共4页Basic and Clinical Medicine

摘　　要：目的评价术后吗啡静脉镇痛泵中加入昂丹司琼预防术后恶心呕吐的有效性。方法对2012-01-01-06-30北京协和医院女性全麻＋术后吗啡静脉镇痛患者进行单因素回顾性分析。结果578例女性患者纳入最终分析，其中术后吗啡静脉镇痛泵中未加入昂丹司琼55例，加入昂丹司琼523例[昂丹司琼（0．2—0．5）mg／h，持续泵入48h]。两组问术后静息疼痛视觉模拟评分（VAS）最大值、活动后疼痛视觉模拟评分最大值以及术后镇静评分均无差异。术后恶心评分最大值以及术后48h内累计呕吐次数无差异。结论女性术后吗啡静脉镇痛泵中加入昂丹司琼并不能减少术后恶心呕吐的发生。Objective To evaluate whether ondansetron added to intravenous patient analgesia solution with mor- phine will reduce postoperative nausea and vomiting. Methods Data of surgical female inpatients in PUMCH from January 1 st to June 30th, 2012 who performed general anesthesia and intravenous analgesia solution with morphine postoperatively were analyzed. Results Data from 578 cases were analyzed. Cases of no adding ondansetron to in- travenous analgesia solution were 55, compared to adding ondansetron group were 523 [ ondansetron （0.2 0. 5） mg/h for 48 hours]. The maximum VAS score of postoperative pain at rest, the maximum VAS score of post- operative pain during movement and postoperative sedation scores were no significantly different. The maximum score of postoperative nausea, and cumulated frequency of postoperative vomiting during first 48 hours were not sig- nificantly different. Conclusions Ondansetron added to intravenous patient-control analgesia solution with mor- phine could not reduce postoperative nausea and vomiting in female patients.

关 键 词：术后恶心呕吐 昂丹司琼 静脉患者自控镇痛 视觉模拟评分 

分 类 号：R614.27[医药卫生—麻醉学]