掺镧羟基磷灰石涂层的合成和性能表征  

Synthesis and characterization of lanthanum-incorporated hydroxyapatite coatings

作　　者：楼维维 董伊雯 金逸凡 刘劲松[2] 

机构地区：[1]温州医科大学,浙江省温州市325027 [2]温州医科大学附属口腔医院,浙江省温州市325027

出　　处：《中国组织工程研究》2014年第8期1224-1230,共7页Chinese Journal of Tissue Engineering Research

基　　金：浙江省大学生科技创新活动计划(新苗人才计划)资助项目(2012R413038);国家自然科学基金项目(81371182;81271186);浙江省自然科学基金项目(LY13H140005);浙江省医药卫生科技计划项目(2013KYA124)~~

摘　　要：背景:在钛基体表面涂覆羟基磷灰石涂层能改善钛表面生物活性,诱导骨生长,但纯羟基磷灰石力学性能较差,易在生理环境中降解,影响种植体的稳定性。目的:研究掺镧羟基磷灰石涂层的合成方法及其性能表征。方法:采用溶胶-凝胶法制备纯羟基磷灰石和掺镧质量分数10%,20%,30%的掺镧羟基磷灰石,通过浸渍-提拉法在钛基体上制备纯羟基磷灰石涂层与掺镧羟基磷灰石涂层。扫描电镜观察掺镧羟基磷灰石涂层的形貌和晶粒微观结构,X射线衍射和傅里叶红外光谱分析其基团结构,原子吸收光谱测定Ca2+浓度来分析涂层的降解性能。结果与结论:随着掺镧量的增加,羟基磷灰石衍射峰更强,结晶度更高,但对羟基磷灰石的整体结构影响较小,可维持晶体结构的稳定和电荷平衡。掺镧羟基磷灰石涂层均匀致密,与钛基底结合紧密,两者之间虽有可见的界面,但没有明显缝隙和裂纹,提示涂层具有较好的结合强度。通过模拟生物环境测定释放的钙离子得出掺镧羟基磷灰石抗酸性更强。BACKGROUND：Hydroxyapatite-coated titanium substrates improve the biocompatibility and have the property of intimating ossteointegration with host bonebed. However, hydroxyapatite lacks the necessary mechanical strength and degrades easily in the extracelular fluids, which may affect the stability of the titanium implant. OBJECTIVE：To study the synthesis and characterization of lanthanum-incorporated hydroxyapatite coatings. METHODS： Lanthanum-incorporated hydroxyapatite coatings were prepared by hydroxyapatite and 10%, 20% and 30% lanthanum, respectively, by means of sol-gel, which were then deposited on titanium substrates with dip-withdrawal technique. Surface morphology and crystaline microstructure of the coatings were observed by scanning electron microscope. The presence of functional groups for the obtained samples was performed by Fourier transform infrared absorption spectroscopy and X-ray diffraction. The Ca2＋ concentration released from the coatings was measured by atomic absorption spectrometry for analysis of degradation property. RESULTS AND CONCLUSION： With the increase of lanthanum content, the diffraction peak and crystalinity of lanthanum-incorporated hydroxyapatite coatings were increased, but the whole structure of lanthanum-incorporated hydroxyapatites had little changes. The crystal structure maintained stable with charge balance. The lanthanum-incorporated hydroxyapatite coatings showed uniform and high-dense structure and were free of cracks, indicating the coatings had good bonding strength. Under the simulated biological environment, based on the determination of Ca2＋ release from the coatings, we can conclude the lanthanum-incorporated hydroxyapatite coatings have a stronger acidoresistance.

关 键 词：生物材料 口腔生物材料 羟基磷灰石 钛 镧 溶胶-凝胶 涂层 扫描电镜 X射线衍射 红外光谱 原子吸收光谱 降解 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]