Survivin,CyclinD1和Caspase-3在皮肤扁平苔藓皮损中的水平  

The Expression of Survivin,CyclinD1 and Caspase-3 in Lesional Skin of Patients with Lichen Planus

作　　者：张雪梅[1] 张娟[2] 吕德华[3] 于洋[1] 姚战非[1] 

机构地区：[1]内蒙古民族大学附属医院皮肤科,内蒙古通辽028000 [2]内蒙古民族大学医学院病理教研室,内蒙古通辽028000 [3]哈尔滨市第一医院耳鼻喉科,黑龙江哈尔滨150010

出　　处：《中国皮肤性病学杂志》2014年第4期346-348,361,共4页The Chinese Journal of Dermatovenereology

基　　金：内蒙古自治区自然科学基金项目(2011MS1181)

摘　　要：目的探讨Survivin,CyclinD1和Caspase-3在皮肤扁平苔藓(lichen planus,LP)中的表达及意义。方法应用免疫组织化学SP法对30例皮肤扁平苔藓患者皮损和10例正常人对照皮肤中Survivin,CyclinD1和Caspase-3的水平进行了检测。结果皮损中三者的阳性表达率均明显高于正常皮肤,差异有统计学意义(P<0.05);30例LP患者皮损的Survivin和CyclinD1的表达具有明显的相关性(P<0.05),Survivin和Caspase-3之间无相关性(P>0.05)。结论 Survivin,CyclinD1和Caspase-3在皮肤扁平苔藓中表达上调。Objective To investigate the expression of Survivin, CyclinD1 and Caspase-3 in LP lesional skin. Methods The expression of Survivin, Caspase-3, CyclinD1 in 30 cases LP skin tissue and ten normal skin tissue were detected by immunohistochemical stain. Results Positive rates of Survivin, CyclinD1, Caspase-3 in LP lesions were significantly higher than those in normal skin（ P 〈 0. 05 ）. Spearman analysis showed that Survivin and CyclinD1 expression had the obvious correlation（P 〈 0. 05 ）, Survivin and Caspase-3 expression had no correlation（P 〉 0.05）. Conclusion The expression of Survivin, CyclinD1 and Caspase-3 in lichen planus slightly higher than that in the normal group.

关 键 词：扁平苔藓 SURVIVIN CYCLIND1 CASPASE-3 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]