中药复方ZDS对烧伤大鼠门静脉血清SOD、MDA的影响  

Effects of Chinese Medicine Compound ZDS on Serum SOD and MDA of Burn Rats

作　　者：张栩[1] 徐锦雄[2] 李锦鸣[1] 汪虹[2] 王丽[3] 陈斌[2] 

机构地区：[1]昆明医科大学第二附属医院中医科,云南昆明650101 [2]昆明医科大学第二附属医院烧伤科,云南省烧伤研究所,云南昆明650101 [3]昆明医科大学,云南昆明650500

出　　处：《昆明医科大学学报》2014年第2期5-7,共3页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(5Y0307C)

摘　　要：目的探讨中药复方ZDS对烧伤后消化道氧自由基损害的保护作用.方法 20只SD大鼠随机分为中药复方ZDS组(ZDS,n=10)和单纯烫伤组(Con,n=10),复制30%TBSA III度烫伤模型后分别于伤后2 h开始给予ZDS或温水灌喂,2 mL/次,2次/d.并于伤后第3、9天观察门静脉血清超氧化物歧化酶(SOD)活力、丙二醛(MDA)水平、肠外组织器官细菌移位率(BT)及肠粘膜病理学改变.结果 ZDS组伤后第9天门静脉血清SOD活力显著高于Con组(P<0.05),而MDA水平则低于Con组(P<0.05).结论中药复方ZDS可在一定程度上降低烧伤后消化道氧自由基损害.Objective To investigate the protective effects of Chinese medicine compound ZDS against digestive tact damage caused by oxygen free radical after the burns. Methods 20 SD rats were randomly divided into ZDS （with ZDS treatment,n=10） and Con （control,n=10） groups. The rats were inflicted with 30%TBSA full thickness burn on the back and fed with Chinese medicine compound ZDS or warm water （2 mL/time,2 times a day） . On the 3rd and 9th postburn day, the serum samples were harvested from portal vein and the serum superoxide dismutase （SOD） activity,the levels of malondiadehycle （MDA） were detected. Meanwhile, the bacteria translocation of parenteral organs and the histology of intestine were also observed. Results The SOD activity in ZDS group on day 9 post burn increased significantly than that in Con group（ ＆lt;0.05）;but at the same timepoint, compared with Con group, the MDA level in ZDS group was decreased obviously （ ＆lt;0.05） . Conclusion Chinese medicine compound ZDS can partly protect the digestive tact against damage caused by oxygen free radical after the burns.

关 键 词：中药复方 烧伤 

分 类 号：R644[医药卫生—外科学]