3.0T MR磁敏感加权成像对早期帕金森病黑质致密带的研究  

3.0T MR Susceptibility-weighted Imaging for Substantia Nigra Pars Compacta in Primary Parkinson's Disease

作　　者：王波[1] 安鸿飞[1] 张洁[1] 毕国力[1] 吴昆华[1] 任丽香[1] 沈凌[2] 

机构地区：[1]云南省第一人民医院磁共振科,云南昆明650032 [2]昆明医科大学健康研究所,云南昆明650500

出　　处：《昆明医科大学学报》2014年第2期27-30,共4页Journal of Kunming Medical University

基　　金：云南省应用基础研究计划基金资助项目(2011FB21B)

摘　　要：目的应用3.0 T磁共振磁敏感加权成像技术T2*图,探讨其在早期帕金森病(PD)研究中的价值.方法采用3.0T磁共振成像系统对59例原发性早期帕金森患者组及59名年龄、性别相匹配的正常对照组进行常规序列及SWI序列的扫描.经后处理在T2*图上分别手动测量双侧SNc宽度、中脑直径的比值(SNc宽度/中脑直径)、SNc的T2*值,并对测量结果进行对比分析.结果 (1)PD症状同侧与正常对照组在SNc宽度、SNc宽度与中脑直径比值、T2*值有统计学意义(P<0.05);(2)PD症状对侧与正常对照组在SNc宽度与中脑直径比值及T2*值有统计学意义(P<0.05),而在SNc宽度差异无统计学意义(P>0.05).结论采用SWI测量SNc的T2*值、宽度以及宽度与中脑直径比值对诊断PD具有一定的临床价值.Objective To evaluate the application of measurement of T2＊value,width of substantia nigra pars compacta （SNc） and the ratio of the width to the midbrain diameter in diagnosing Parkinson disease （PD） in early stage with susceptibility weighted imaging （ SWI） by 3T MR. Methods 59 patients with early stage idiopathic PD patients and 59 healthy controls,ranging in same ages and gender,had been scanned with routine sequences and SWI sequences by 3T MR. T2＊value,width and the ratio of the width to the midbrain diameter of SNc were measured. The results of measurement were analyzed and compared. Results （1） The T2＊values, width and the ratio of the width to the midbrain diameter was decreased in homolateral side SNc of symptoms of subjects with PD compared with the healthy controls （P〉0.05） . （2） There was a significant reduction in the T2＊values and the ratio of the width to the midbrain diameter in contralateral side SNc symptoms of subjects with PD compared with the healthy controls （P＆lt;0.05） . There was no differences in width of SNc （ P〉0.05） . Conclusion Measurement of T2＊value, width and the ratio of the width to the midbrain diameter of SNc with SWI is reliable to diagnose PD.

关 键 词：帕金森病 黑质致密带 脑铁沉积 

分 类 号：R817.4[医药卫生—影像医学与核医学]