NT-proBNP在老年心源性胸腔积液患者鉴别诊断中的价值探讨  

The Diagnostic Value of Determination of NT-pro BNP in Elderly Patients with Cardiac Pleural Effusion

作　　者：钟海波[1,2] 粱忆华 汪得喜[1,2] 

机构地区：[1]广州市红十字会医院 [2]广东省暨南大学第四附属医院,510220

出　　处：《岭南急诊医学杂志》2014年第1期1-2,6,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省科技计划资助项目(2004B36001032)

摘　　要：目的:探讨血清及胸腔积液氨基末端B利钠肽前体(NT-proBNP)水平在老年心源性胸腔积液患者鉴别诊断中的价值。方法:回顾性分析62例住院老年患者血清及胸腔积液NT-proBNP水平及其他生化结果。结果:患者血清和胸腔积液NT-proBNP水平无显著差异(2885±4697pg/ml&2725±4600 pg/ml,P>0.05);心源性胸腔积液NT-proBNP水平显著高于非心源性胸腔积液(P<0.001);在诊断心源性胸腔积液方面,血清、胸腔积液NT-proBNP cutoff值分别为1563.0 pg/ml、1500.5 pg/ml;以NT-proBNP浓度>1 500 pg/ml为判断心源性胸腔积液的截点,其敏感性、特异性及约登指数分别为85.7%、92.3%和83.1%。结论:检测胸腔积液NT-proBNP有助于鉴别老年患者心源性因素所致的胸腔积液。Objective ：To explore the differential diagnosis value of the determination of amino terminal B natriuretic peptide precursor （NT-proBNP）levels in serum and hydrothorax in elderly patients with cardiac pleural effusion. Method： The results of NT-proBNP level and other biochemical in serum and hydrothorax in elderly patients with cardiac pleural effusion were analyzed retrospectively. Results：The NT-proBNP level in serum and hydrothorax in the 62 cases were no significant difference （2885±4697 pg/ml ＆ 2725±4600,P〉0.05）. The NT-proBNP of cardiac pleural effusion was significantly higher than that of non cardiac pleural effusion（P〈0.001 ）.In the diagnosis of cardiac pleural effusion, serum and pleural effusion NT-proBNP cutoff value was 1563.0 pg/ml and 1500.5 pg/ml respectively. If the NT-proBNP concentration 〉1500 pg/ml in pleural effusion can be considered,cardiac pleural effusion of the cutoff point, the sensitivity, specificity and about an index were 85.7%, 92.3%, 85.7%. Conclusion ： The determination of NT-proBNP levels in hydrothorax will help identifying elderly patients with pleural effusion caused by cardiac factors.

关 键 词：氨基末端B利钠肽前体 胸腔积液 老年人 心力衰竭 

分 类 号：R561.3[医药卫生—呼吸系统]