烧伤后增生性瘢痕患者血清中TGF-β和VEGF的浓度检测及意义  

Research of change of serum concentration of cytokines TGF-βand VEGF of postburned hypertrophic scars

作　　者：沈锐[1] 张金明[2] 张凤刚[1] 陈晓东[1] 杜永军[3] 徐路生[3] 宋红梅[4] 

机构地区：[1]中山大学附属佛山医院烧伤整形外科,广东佛山528000 [2]中山大学第二附属医院整形外科,广东广州520120 [3]中山大学附属佛山医院手足整形外科,广东佛山528000 [4]中山大学附属佛山医院门诊,广东佛山528000

出　　处：《中国美容医学》2014年第4期292-295,共4页Chinese Journal of Aesthetic Medicine

基　　金：佛山市重点科技攻关项目(No.200808053);佛山卫生局项目(No.2008054)

摘　　要：目的：探讨烧伤后增生性瘢痕患者血清中TGF-β、VEGF浓度变化及意义.方法：选择2009,8～2011,8我科住院的烧伤后增生性瘢痕患者共74例,根据创面愈合后瘢痕增生时间长短分组,分为4组,选择12例正常人作为正常对照组,共5组.用酶联吸附法（ELISA）检测患者血清中TGF-β、VEGF的浓度,5组之间统计比较分析.结果：瘢痕患者血清中TGF-β、VEGF含量与瘢痕增生时段关系密切,1～3月早期瘢痕组血清中TGF-β、VEGF含量开始增加,随瘢痕的发展升高,4～6个月瘢痕组血清中TGF-β、VEGF含量达到了高峰.随着瘢痕成熟,TGF-β、VEGF浓度又逐渐下降.结论：烧伤后增生性患者血清中TGF-β、VEGF的含量可较好地反映增生性瘢痕代谢活跃程度,是增生性瘢痕增生活跃程度敏感的标记物.Objective To explore the dose and its clinic significance of profibrotic cytokines of TGF-βand VEGF in the serum of hypertrophic scar patients at excessive stages.Methods Collected serum samples of 74 inpatients admitted in our hospital between 2009,8 and 2011,8 suffering from post-burned hypertrophic scars at various stages.Serum samples of 12 cases of healthy persons were also collected as control group.Hypertrophic scar group were divided into 4 subgroups according to the phase of scars and detected the concentrations of TGF-βand VEGF in serum of the trials using the ELISA method.Results The doses of TGF-βand VEGF began to increase in 1 to 3 months hypertrophic scar group and achieved summit concentration in 4 to 6 months scar group.The concentration of TGF-β and VEGF degreased gradually with the maturation of hypertrophic scars Conclusions High concentration of TGF-βand VEGF in the serum can reflect the level of metabolic activity in the tissue of hypertrophic scars.TGF-βand VEGF may be one promising marker in discerning the growth and development of hypertrophic scars.

关 键 词：增生性瘢痕 烧伤后 血清 标记物 TGF-Β VEGF 

分 类 号：R619.6[医药卫生—外科学]