骨质疏松相关信号通路研究进展  

Research progress of signaling pathways in osteoporosis

作　　者：查小云[1] 胡予[1] 

机构地区：[1]复旦大学附属中山医院老年科,上海200032

出　　处：《中国骨质疏松杂志》2014年第2期205-209,共5页Chinese Journal of Osteoporosis

摘　　要：骨代谢过程包括骨形成及骨吸收,当两者间的平衡被打破后便会出现骨硬化或者骨量减少甚至骨质疏松,其具体的分子调节通路不明。现代研究表明,在骨代谢过程中至少存在RANKL/RANK/OPG信号通路、Wnt/β-catenin信号通路、PTH信号通路、PPAR-γ信号通路等,各个通路间还存在交叉。通过分子信号通路,可有效促进骨代谢研究,并开发具有治疗骨质疏松的新药。Bone metabolism consists of bone formation and bone resorption osteopenia, or even osteoporosis, but the specific signal pathway remains The imbalance between them causes osteosclerosis, unknown. Current researches reveal that at least 4 signaling pathways participate in bone metabolism： RANKL/RANK/OPG signaling pathway, Wnt/β-catenin signaling pathway, PTH signaling pathway, and PPAR-γ, signaling pathway. And the cross-talks exist between pathways. Through the signaling pathways, we can promote the study of bone metabolism and develop new drugs to treat osteoporosis.

关 键 词：骨质疏松 信号通路 RANKL/RANK/OPG信号通路 Wnt/β-catenin信号通路 PTH信号通路 PPAR-γ信号通路 

分 类 号：R589[医药卫生—内分泌]