帕瑞昔布钠复合地佐辛预防全身麻醉苏醒期躁动的临床研究  

作　　者：马国才[1] 元春梅[1] 王远胜[1] 

机构地区：[1]广东省江门市中心医院,广东529000

出　　处：《当代医学》2014年第8期81-82,共2页Contemporary Medicine

摘　　要：目的观察帕瑞昔布钠复合地佐辛预防全身麻醉苏醒期躁动的作用。方法全身麻醉下行择期甲状腺切除术患者120例随机均分为帕瑞昔布钠组(P组)、帕瑞昔布钠+地佐辛组(PD组)、地佐辛组(D组)和等容生理盐水组(C组)4组(n=30)。P组麻醉诱导前静注帕瑞昔布钠40 mg组、PD组麻醉诱导前静注帕瑞昔布钠40 mg并手术结束前30 min静注地佐辛0.1 mg/kg、D组手术结束前30 min静注地佐辛0.1 mg/kg,C组给予等容生理盐水。观察苏醒期躁动的发生情况。结果与C组比较,P、PD、D组苏醒期躁动发生显著减少(P<0.01),BCS分级和Ramsay评分更高(P<0.01),VAS评分更低(P<0.01);与P组和D组比较,PD组苏醒期躁动发生显著减少(P<0.05或0.01),BCS分级和Ramsay评分更高(P<0.05或0.01),VAS评分更低(P<0.05或0.01)。结论帕瑞昔布钠40 mg复合地佐辛0.1 mg/kg能更好地预防全身麻醉苏醒期躁动,有效提高苏醒期质量。Objective To observe the effect of parecoxib combined dezocine on preventing agitation during wake-up from general anesthesia. Methods A total of 120 patients undergoing selective thyroidectomy under general anesthesia were randomly divided into 4 groups with 30 cases each. Group P received parecoxib 40 mg iv before induction of anesthesia, group PD received parecoxib 40 mg iv before induction of anesthesia plus dezocine 0.1 mg/kg iv 30 min before the end of operation, group D received dezocine 0.1 mg/kg iv 30 min before the end of operation,group C received equal volume of normal saline. The occurrence of agitation was observed during waking-up period in PACU. Results The rates of agitation was signiifcantly decreased in group s of P,PD and D than that in group of C ,The BCS and Ramsay values were higher and VAS values were lower than that in group of C. Conclusion Parecoxib 40 mg combined 0.1 mg/kg of dezocine can safely and effectively prevent the incidence of emergence agitation, so that to ensure the patients during analqesia period .

关 键 词：帕瑞昔布钠 地佐辛 苏醒期躁动 

分 类 号：R614[医药卫生—麻醉学]