自乳化粒径表征方法及其规律初步探索  

Preliminary Exploration of Self-emulsifying Particle Size Characterization Methods and Its Regularity

作　　者：朱双燕 崔名全[2] 胡凤 王浩[2] 余泉毅 赵俊霞[2] 苏建春[2] 

机构地区：[1]自贡市食品药品检验所,四川自贡643010 [2]成都中医药大学,四川成都611137

出　　处：《中国中医药信息杂志》2014年第3期71-74,共4页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的：探求自乳化粒径的表征方法并对比各种方法之间存在的规律性。方法通过设定浊度标准液的澄明度等级，选择2种难溶性药物--二萜内酯类化合物穿琥宁和二氢吡啶类药物硝苯地平为模型药物，从不同三元相图中选择形成乳液澄明度等级不同的10～12个处方，用激光粒度扫描仪测定其粒径，用紫外-可见分光光度法测定其吸光度，绘制图表，比较3种粒径表征方法的规律。结果同一相图中的处方形成乳液乳滴的粒径、吸光度与澄明度等级存在正相关关系，但不同相图的处方形成乳液乳滴的粒径、吸光度与澄明度无规律性。结论辅料和药物均相同但比例不同的处方形成乳液乳滴的粒径，可以通过目测法观察其澄明度或用紫外-可见分光光度计测定其吸光度来比较。Objective To explore self-emulsifying particle size characterization methods and compare the regularity of various methods. Methods By setting the clarity level of turbidity standard solution, with two less soluble drugs-diterpene lactone compounds Chuanhuning and dihydropyridine drug nifedipine as model drugs, 10-12 clarity level prescriptions were selected from six different ternary phase diagram. Laser particle size scanner was used to determine the particle size, and UV-visible spectrophotometry to determine its absorbance. Three methods of particle size characterization rules were compared by drawing charts. Results There was a positive correlationship among droplet particle size, absorbance and clarity grade of emulsion formed by prescription in the same phase diagram. But, there was no regularity among droplet particle size, absorbance and clarity grade of emulsion formed by prescription in different phase diagram. Conclusion The droplet particle size of emulsion formed by prescription containing the same drugs and excipients in different proportions can be compared by clarity with visual method or absorbance with UV-visible spectrophotometer.

关 键 词：自乳化 粒径 澄明度等级 吸光度 表征方法 三元相图 

分 类 号：R283.5[医药卫生—中药学]