正交试验法优化白金胶囊中合欢花提取工艺  

Optimization of Extraction Process for Albizia julibrissin in Baijin Capsule by Orthogonal Test

作　　者：张慧[1] 张晋[1] 祁娟娟[1] 党晓芳[1] 曹飒丽[1] 倪健[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中医药信息杂志》2014年第3期78-80,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81173563);国家科技重大专项-重大新药创制(2012ZX09103201-026);北京中医药大学复方中药制药创新团队(2011-CXTD-13)

摘　　要：目的优化筛选白金胶囊中合欢花的提取工艺。方法以合欢花中槲皮苷及总黄酮的提取率作为评价指标,采用正交设计法考察溶剂用量、提取时间、提取次数对提取结果的影响,确定最佳提取工艺。结果合欢花的最佳提取工艺为:采用12倍量70%乙醇,回流提取2次,每次2 h。结论该提取工艺简便易行、稳定可靠,可为白金胶囊的实际生产提供依据。Objective To optimize the extraction process of Albizia julibrissin in Baijin Capsule. Methods Using the extraction rate of quercitrin and total flavonoids as indexes, the orthogonal design was used to investigate effects of solvent volume, extraction time and extraction frequency on extraction results. Results The optimal extracting condition was as follows：extracted 2 times with 12 fold 70%alcohol, 2 h for each time. Conclusion The optimized process condition was simple, stable and feasible. It provides the basis for the production of Baijin Capsule.

关 键 词：正交试验 合欢花 白金胶囊 提取工艺 

分 类 号：R283.5[医药卫生—中药学]