正交试验法优选降糖通络颗粒提取工艺  

Optimization of Extraction Processing Technology of Jiangtang Tongluo Granule by Orthogonal Experiment

作　　者：刘丽侠[1,2] 申林卉 陶遵威[2] 

机构地区：[1]天津中医药大学,天津300073 [2]天津市医药科学研究所,天津300020

出　　处：《中国中医药信息杂志》2014年第3期81-83,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：天津市中医药管理局中医;中西医结合科研课题(11083)

摘　　要：目的优选降糖通络颗粒的最佳提取工艺。方法采用正交试验法,以加水量、提取次数、提取时间为因素,出膏率和芍药苷含量为考察指标,采用高效液相色谱法对芍药苷含量进行检测,以确定最佳提取工艺。结果降糖通络颗粒的最佳的提取工艺为:药材加10倍量水,煎煮3次,每次1 h。结论该工艺条件合理,稳定可行,为该制剂的生产和质量控制奠定了基础。Objective To investigate the optimal extraction process of Jiangtang Tongluo Granule. Methods The orthogonal design was used in the extraction, according to the yield rate and content of paeoniflorin, with the volume of water, extraction times and extraction time as factors. The content of paeoniflorin was detected by HPLC method to determine the best extraction technology. Results The optimal water extracting technology of Jiangtang Tongluo Granule was performed by 1 h extraction for 3 times, with 10-fold volume of water. Conclusion The process is stable, feasible and reasonable, and provides a foundation for the further production and quality control.

关 键 词：降糖通络颗粒 正交试验 提取工艺 芍药苷 

分 类 号：R283.5[医药卫生—中药学]