诱导头孢噻肟钠结晶过程研究  

Induced Crystallization of Cefotaxime Sodium

作　　者：尹永恒[1] 鲍颖[1,2] 王永莉[1] 高振国[1] 刘东 

机构地区：[1]天津大学化工学院,天津300072 [2]天津市现代药物传递及功能高效化重点实验室,天津300072 [3]华北制药集团有限责任公司,石家庄050015

出　　处：《化学工业与工程》2014年第2期48-53,共6页Chemical Industry and Engineering

基　　金：天津市自然科学基金重点项目(13JCZDJC28400)

摘　　要：在头孢噻肟钠溶析结晶过程中,容易发生胶凝。为了控制结晶过程,避免胶凝,使用在线技术考察了3种晶种以及超声波对头孢噻肟钠结晶过程的影响。结果表明,晶种不仅影响产品的粒度分布和晶习,还会影响产品收率以及纯度。研磨晶种能够有效促进成核,显著消耗过饱和度,从而抑制胶凝的发生,促进头孢噻肟钠结晶。超声波也能起到促进成核的作用。研磨晶种的比表面积较大且表面粗糙是其有效诱导头孢噻肟钠结晶的重要因素。Cefotaxime sodium is easy to gelate during anti-solvent crystallization. Aiming at controlling crystallization process and avoiding gelation, different seeds were used to investigate their effects on the anti-solvent crystallization of cefotaxime sodium. The effect of ultrasonic on the crystallization process was also investigated. Crystallization process was monitored using process analytical technologies. The results show that the seeds affect not only the crystal size distribution and crystal shape, but also the crystal puri- ty and yield. The milled seeds can effectively induce nucleation and crystal growth, consume the super- saturation and then avoid gelation. The ultrasonic can induce nucleation as well. The results also shows that specific surface area and surface roughness of the seed crystal are the key factors inducing crystalliza- tion of cefotaxime sodium.

关 键 词：头孢噻肟钠 晶种 溶析结晶 成核 超声波 

分 类 号：TQ026.5[化学工程]