再灌注治疗中缺血心肌的保护策略  

The Protection Strategies of Reperfusion Treatment of Ischemic Myocardium

作　　者：谢倩倩[1] 张俊峰[2] 

机构地区：[1]蚌埠医学院,安徽蚌埠233030 [2]上海交通大学医学院附属第三人民医院心内科,上海201900

出　　处：《医学综述》2014年第4期584-587,共4页Medical Recapitulate

基　　金：上海市宝山区科委课题(10-E-4)

摘　　要：心肌缺血/再灌注中存在着不同程度的心肌损伤,并且理论上难以避免。如何减少缺血/再灌注心肌损伤已成为心肌保护的研究热点之一。目前保护缺血损伤心肌的研究大量涌出,主要方法有缺血预处理、缺血后处理、控制性再灌注等,旨在提高再灌注疗效,改善患者预后。该文就心肌缺血/再灌注损伤的机制、保护缺血心肌免受损伤的两种主要方法及其现状进行综述,并进一步阐述它们的应用前景。Myocardial injury with different degrees can be found in myocardial isehemia/reperfusion, which is difficult to avoid in theory. How to reduce ischemia/reperfusion injury is one of the hot spots in myo- cardial preservation. At present, there are a lot of studies about protecting the heart against isehemic myocar- dial injury, such as, ischemic preconditioning, ischemic posteonditioning and controlled reperfusion, to improve reperfusion curative effect and prognosis of patients. Here is to make a review of the mechanism of myocardial ischemia/reperfusion injury, two kinds of main methods to protect ischemic myocardium from damage and their current situation, and the application prospect.

关 键 词：缺血 再灌注损伤 缺血后处理 控制性再灌注 

分 类 号：R542.2[医药卫生—心血管疾病]