子宫内膜雌、孕激素受体及整合素β_3表达与胚胎移植异位妊娠的关系  

Relationship between Expression of Endometrial Estrogen and Progesterone Receptors,Integrin β3 and Ectopic Pregnancy of IVF /ICSI-ET

作　　者：张敏旗[1,2] 杜敏[1,2] 邱耀芳[1,2] 叶丽霞[1,2] 

机构地区：[1]深圳市第五人民医院 [2]罗湖区人民医院生殖医学中心,广东深圳518001

出　　处：《医学综述》2014年第4期717-719,共3页Medical Recapitulate

基　　金：深圳市科技计划项目(201003439)

摘　　要：目的探讨子宫内膜雌激素受体(ER)、孕激素受体(PR)、整合素β3表达与体外受精/卵母细胞单精子显微注射-胚胎移植(IVF/ICSI-ET)后异位妊娠的相关性。方法选择2010年7月至2012年1月深圳市第五人民医院收治的因男方因素、不明原因不孕实施IVF/ICSI-ET的患者106例,根据其助孕结局分为未孕组46例、宫内孕组39例、异位妊娠组21例,测定IVF/ICSI-ET治疗前周期黄体期子宫内膜ER、PR、整合素β3的表达。结果宫内孕组整合素β3子宫内膜上皮细胞的阳性表达最强,未孕组最弱;异位妊娠组和未孕组ER、PR表达强于宫内孕组,差异有统计学意义(P<0.05)。结论 ER、PR、整合素β3在子宫内膜异常表达,可导致子宫内膜容受性下降,可能增加异位妊娠的发生风险。ObjectiveTo evaluate the relationship between expression of endometrial estrogen receptors and progesterone receptors,integrin β3 and ectopic pregnancy of IVF/ICSI-ET.MethodsA total of 106 women with male infertility or unexplained infertility underwent IVF/ICSI-ET in Shenzhen Fifth People＇s Hospital from Jul.2010 to Jan.2012 were collected,including 46 cases who failed to be pregnant,39 cases who successfully became pregnant and 21 cases were ectopic pregnancy.SP was performed to detect the expression of ER,PR,and integrin β3 in endometrial samples.ResultsThe integrin β3 expressions in the pregnant group were higher than the non-pregnant group and the ectopic pregnancy group.The differences between the three groups was significant（P〈0.05）.ER and PR expressions in the non-pregnant group and the ectopic pregnancy group were higher than the pregnant group.ConclusionAbnormal expression of endometrial ER,PR and integrin can decrease endometrial receptivity,and may increase the risk of ectopic pregnancy.

关 键 词：整合素Β3 雌激素 孕激素 受体 异位妊娠 子宫内膜 

分 类 号：R711.6[医药卫生—妇产科学]