微粒化黄体酮调控功能失调性子宫出血及闭经患者月经周期的效果  

The effects of micronized progesterone on regulation of menstrual cycle for patients with dysfunctional uterine bleeding and amenorrhea

作　　者：龙腾飞[1] 丁淼[1] 王良岸[1] 谢梅青[1] 

机构地区：[1]中山大学孙逸仙纪念医院妇产科,广州510120

出　　处：《广东医学》2014年第4期588-591,共4页Guangdong Medical Journal

基　　金：广东省农村信息直通车工程项目(编号:2011A020600010)

摘　　要：目的 评价口服微粒化黄体酮胶囊用于调控闭经及无排卵性功能失调性子宫出血（功血）患者的月经周期疗效及不良反应.方法 将前来就诊的60例15～43岁确诊为下丘脑-垂体或卵巢性闭经及无排卵性功血的患者随机分为两组进行人工周期调经治疗.观察组40例接受戊酸雌二醇片与微粒化黄体酮胶囊治疗,共3个周期;对照组20例接受戊酸雌二醇片与醋酸甲羟孕酮片治疗,共3个周期.观察患者月经周期、月经期时间及月经量变化,测量用药前及用药3个周期后的体重、腰围,B超测量月经期11～14 d子宫内膜厚度,检测月经期血清卵泡刺激素、黄体生成素及雌二醇水平.结果 两组用药前月经期及月经周期、子宫内膜厚度差异均无统计学意义（P〉0.05）;用药后两组月经期、子宫内膜厚度差异无统计学意义（P〉0.05）;但月经周期差异有统计学意义（P〈0.05）.对照组中功血患者治疗前后月经周期、月经期及子宫内膜厚度差异均有统计学意义（P〈0.05）;观察组中功血患者治疗前后月经期及子宫内膜厚度差异有统计学意义（P〈0.05）;但月经周期差异无统计学意义（P〉0.05）.观察组中闭经患者治疗前后月经周期差异有统计学意义（P〈0.05）;月经期及子宫内膜厚度差异均无统计学意义（P〉0.05）;对照组中闭经患者治疗前后月经周期及月经期差异有统计学意义（P〈0.05）;但子宫内膜厚度差异无统计学意义（P〉0.05）.两组不良反应发生率分别为12.5%（5/40）及10.0%（2/20）,差异无统计学意义（P〉0.05）.结论 微粒化黄体酮胶囊用于人工周期治疗时,能有效调控月经周期、月经期及月经量,不良反应少.Objective To evaluate the effects of micronized progesterone on regulation of the menstrual cycle for patients with dysfunctional uterine bleeding （DUB） and amenorrhea. Methods Sixty women of 15~43 years old, who were diagnosed with hypothalamus pituitary or ovarian genic anovulatory DUB and amenorrhea from 2011 July to June 2012, were randomly divided into two groups for artificial menstrual cycle therapy. The study group （MP group） with 40 patients received the treatment of estradiol valerate tablets and micronized progesterone capsules for 3 cycles; while the control group （MPA group） with 20 patients received the treatment of estradiol valerate tablets and medroxyprogesterone acetate tablets for 3 cycles. The changes in the menstrual cycle, period and menstrual blood volume, body weight, and waist circumference before and after treatment were recorded; the endometrial thickness was measured by B ultrasound during the 11~14 days of the menstruation; and serum FSH, LH and E2 during the menstrual period were also assessed. Results There was no significant difference in menstrual cycle, menstrual period or endometrial thickness before treatment between the 2 groups （P〉0.05）; neither was in menstrual period or endometrial thickness after treatment （P〉0.05）; however, there was significant difference in the menstrual cycle after treatment between the 2 groups （P〈0.05）. In the MPA group, there were significant differences in menstrual cycles, menstrual periods and endometrial thicknesses before and after treatment in patients with DUB （P〈0.05）. In the MP group, there were significant differences in menstruations and endometrial thicknesses before and after treatment （P〈0.05）; but there was no significant difference in menstrual cycle （P〉0.05）. In patients with amenorrhea in MP group, there was significant difference in menstrual cycles before and after the treatment （P〈0.05）; but not in menstruations or endometrial thicknesses （P〉0.05）. In patients with amen

关 键 词：黄体酮胶囊 功血 闭经 人工周期 

分 类 号：R271.915.2[医药卫生—中西医结合]