雄激素及其受体在卵巢中的作用  

The Role of Androgen and Its Receptor in Ovary

作　　者：王芳芳[1] 潘洁雪[1] 任珺[2] 黄荷凤[3] 

机构地区：[1]浙江大学医学院附属妇产科医院生殖内分泌科,杭州310006 [2]浙江大学医学院教育部生殖遗传重点实验室 [3]上海交通大学医学院附属中国福利会国际和平妇幼保健院

出　　处：《国际妇产科学杂志》2014年第1期14-17,共4页Journal of International Obstetrics and Gynecology

基　　金：国家重大科学研究计划项目(2012CB944900);"十二五"国家科技支撑计划课题(2012BAI32B04;N20120266-01);青年科学基金项目(81100468)

摘　　要：雄激素是卵巢基本功能的重要维持者,通过与雄激素受体结合激活下游的信号通路,从而发挥其生理功能。虽然雄激素及其受体在卵巢卵泡发生过程中发挥的重要作用已被广泛公认,但迄今为止,卵巢中详细的雄激素下游通路尚未明确。对基因敲除小鼠的研究使研究者们对雄激素受体在卵巢卵泡发生过程中作用的理解更加深入。就雄激素及其受体相关分子通路在卵巢中的作用及意义进行了综述。Androgen mediate their action primarily via transcriptionally activating the androgen receptor（AR）,an important factor of androgen signaling pathway. The roles of androgen and AR in female reproductive physiology arise from their biological effect on follicle growth and development both in vitro and in vivo. Although the pivotal role of androgen in male reproductive function is well established,the precise mechanism of it in female reproductive physiology and pathology remains blurred. Recent studies have established several animal models with specific disruption of the AR gene,and this helps us understand the role of AR-mediated action in maintaining female fertility. Here we reviewed androgen and AR signaling pathway in ovary.

关 键 词：雄激素 受体 信号传导 卵巢 卵泡 

分 类 号：R33[医药卫生—人体生理学]